维生素D3通过调节糖尿病前期KKay小鼠的肠道微生物群和代谢物来改善高血糖症
Yujing Zhang1, Peng Ni2, Hao Chen3
1Department of Food Hygiene and Nutrition, School of Medicine, Henan University of Chinese Medicine, Zhengzhou 450000, Henan, China; Department of Nutrition and Food Hygiene, College of Public Health, Zhengzhou University, Zhengzhou 450000, Henan, China.
Food research international (Ottawa, Ont.)
|May 13, 2025
概括
维生素D3补充剂通过改变肠道微生物群和代谢物,改善了糖尿病前小鼠的葡萄糖代谢. 这些有益效应可以通过便微生物群移植转移,突出显示了一种新的治疗方法.
科学领域:
- 内分泌学 在内分泌学.
- 微生物学 微生物学
- 代谢科学 代谢科学
背景情况:
- 糖尿病前期是糖尿病发展的关键阶段,其特点是肠道微生物群的改变.
- 维生素D (VD) 具有抗糖尿病特性,但其与改善高血糖症的肠道微生物群的联系尚不清楚.
研究的目的:
- 为了研究维生素D3 (VD3) 对糖尿病前小鼠葡萄糖代谢的影响.
- 阐明VD3的作用背后的机制,包括其对肠道微生物群和宿主代谢途径的影响.
主要方法:
- 糖尿病前的小鼠接受了不同度的VD3治疗.
- 评估包括生物化学分析,口服葡萄糖耐受性测试,16SrRNA测序和非向代谢学.
- 从VD3治疗小鼠到接受者小鼠进行了便微生物群移植 (FMT),以评估效应的可转移性.
主要成果:
- 在小鼠中,VD3干预缓解了葡萄糖代谢问题.
- 它增强了结肠紧结蛋白,减少了代谢内毒素和炎症,并调节了TNFα诱导的TLR4/NFκB和PI3K/AKT胰岛素信号通路.
- VD3改变了肠道微生物群结构和代谢物,预计会对碳水化合物代谢产生影响. 这些效应可以通过FMT转移.
结论:
- 在糖尿病前的小鼠中,VD3通过调节肠道微生物群和代谢物来改善葡萄糖代谢.
- 在葡萄糖代谢中VD3的治疗效益可以通过便微生物群移植转移,这表明微生物群介导的机制.
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