由于微量水分吸附而没有脱落而引起的L-histidine单化单水晶的凝结
Jung Won Park1, Hyeongseok Han1, Kyochan Kim1
1CJ BIO Research Institute, CJ CheilJedang, Suwon-Si, Gyeonggi-do, 16495, Republic of Korea.
Food research international (Ottawa, Ont.)
|May 13, 2025
概括
在70°C和80%的RH,甚至在0.1%以下的湿度下,L-Histidine单化单 (HIS HCl H2O) 的化发生. 在结晶过程中降低冷却速率有效地通过增加晶体大小来防止凝结.
科学领域:
- 材料科学 材料科学 材料科学
- 化学工程是化学工程的重要组成部分.
- 结晶科学 结晶科学
背景情况:
- 在食品,制药和料工业中广泛使用L-histidine单化单 (HIS HCl H2O).
- 在储存和分销过程中,客户对HIS HCl H2O凝结的投诉很常见.
- 凝结的精确机制和HIS HCl H2O晶体的有效溶液仍未得到充分研究.
研究的目的:
- 为了研究HIS HCl H2O晶体的凝结机制.
- 为了确定导致凝结的关键条件 (温度,相对湿度,水分含量).
- 评估晶体大小对凝结的影响,并探索预防策略.
主要方法:
- 试验测量水分吸附异热体的测量.
- 在各种温度和相对湿度 (RH) 条件下评估凝结程度.
- 在凝结实验之前和之后分析晶体大小分布和多态变化.
主要成果:
- 观察到在70°C和80%的RH温度下,水分含量低于0.1%,没有蒸发性结晶.
- 精细的晶体 (<125μm) 显示出严重的凝结 (99.8%的块产生),而较大的晶体 (500-1000μm) 则没有凝结.
- 颗粒大小分析显示,在凝结过程中,平均颗粒大小 (435.7至475.1微米) 转向更大,没有显著的多态变化.
结论:
- HIS HCl H2O的化强烈依赖于晶体大小,较小的晶体更容易受到影响.
- 在结晶过程中降低冷却速率是增加晶体大小和防止凝结的有效策略.
- 在制造过程中控制晶体大小可以减轻与HIS HCl H2O凝结相关的存储和分配问题.
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