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对乳腺癌免疫疗法免疫细胞作用的系统审查

Rui Li¹, Wei Lv², Dong Liang Wang³

¹Shandong Provincial Hospital, Affiliated to Shandong First Medical University, Jinan, Shandong, China.

Cancer reports (Hoboken, N.J.)

|May 13, 2025

概括

像TAMs,TILs,NK细胞,DCs和MDSCs这样的免疫细胞是乳腺癌 (BC) 进展和免疫治疗反应的关键. 了解它们在瘤微环境 (TME) 中的复杂作用对于开发有效的个性化治疗至关重要.

科学领域:

在瘤学瘤学.
免疫学免疫学免疫学
癌症研究癌症研究

背景情况:

乳腺癌 (BC) 仍然是妇女死亡的主要原因,传统治疗因副作用和耐药性而面临限制.
免疫疗法已经成为一种有前途的方法,突出了免疫细胞在BC治疗中的关键作用.

研究的目的:

系统地审查当前对乳腺癌瘤微环境 (TME) 中免疫细胞作用的理解.
分析BC免疫疗法的各种免疫细胞的表型,功能和影响.

主要方法:

在遵守PRISMA指南的基础上进行系统审查.
分析了2010年至2024年间发表的71项研究.

主要成果:

关键的免疫细胞种群,包括瘤相关的巨细胞 (TAMs),瘤透性淋巴细胞 (TILs),自然杀手细胞 (NK),树突细胞 (DCs) 和髓质衍生抑制细胞 (MDSCs),显著影响瘤的进展和对治疗的反应.
这些免疫细胞的功能异质性和可塑性对开发有效和个性化的免疫治疗策略提出了挑战.

结论:

进一步的研究是必不可少的,以阐明控制BC TME内的免疫细胞行为的机制.
获得这些见解将促进精确免疫疗法和个性化治疗方法的进步,以改善患者的治疗结果和生活质量 (QoL).

关键词:

乳腺癌乳腺癌乳腺癌免疫细胞免疫细胞免疫疗法免疫疗法瘤微环境是一个微环境.疫苗,疫苗的使用情况.

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