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在前中心中前额眼场:用立体EEG电极进行直接电皮层刺激研究

Yang Jin¹, Kaihui Li², Xining Liu¹

¹Department of Neurosurgery, The Affiliated Guangdong Second Provincial General Hospital of Jinan University, Guangzhou, China.

Brain and behavior

|May 13, 2025

概括

直接刺激前中心 (PrCS) 主要会诱导眼动 (EMs),如偏差. 上方的PrCS更有反应性,正的EM与发作区域在PrCS内相关.

科学领域:

神经科学是一个神经科学.
发病学 (Epileptology) 是一个专业的学科.
神经外科神经外科

背景情况:

了解由大脑刺激引起的眼动 (EMs) 对于绘制皮质功能至关重要.
前中心 (PrCS) 参与运动控制,但其在产生EMS中的作用需要进一步阐明.
研究发性区域对刺激诱导的EMS的影响可以改进外科手术向.

研究的目的:

从前中心 (PrCS) 的不同区域绘制刺激诱导的眼动 (EM).
确定发作发作区 (SOZ) 的位置是否会影响EMS的发生和特征.
确定在直接电刺激过程中与正电磁波相关的因素.

主要方法:

从患者的SEEG探索中分析高频直接电刺激映射数据的分析.
对患者人口统计数据,EMS影响,特征和刺激参数的统计分析.
多变量回归以确定积极EMS的预测因素.

主要成果:

在77名患者中的778名接触者中,18名 (23.4%) 在PrCS中显示诱导EM.
优质的PrCS (SP) 产生了比较低质的PrCS (IP) 更多的阳性EM (60.3%对39.7%,p=0.017).
阳性EMS与SOZ位于PrCS (p=0.004) 内的情况有显著的相关性,独立于其他因素.

结论:

眼睛偏差是EMS对PrCS刺激的主要反应.
与IP相比,SP是一个更容易引起EM的敏感区域.
诱导EMS的可能性与PrCS是SOZ的一部分有关.

关键词:

电脑皮层刺激额头眼野预中心发作发作区域

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