雄激素替代疗法对患有阴性恋症的患者认知功能的影响:系统性审查和元分析
Baolong Wang1, Xiaoqiang Liu1, Wenxuan Chen1
1Department of Urology, Tianjin Medical University General Hospital, Tianjin 300052, P.R. China.
Biomedical reports
|May 13, 2025
概括
雄激素替代疗法 (ART) 显著改善了男性的执行功能和记忆力. 虽然ART对认知功能有好处,但对注意力和视觉空间能力的影响不那么明显.
科学领域:
- 内分泌学 在内分泌学.
- 神经科学是一个神经科学.
- 老年学是一门学科.
背景情况:
- 由低丸激素定义的阴性腺症与认知能力下降有关,影响记忆力和执行功能.
- 雄激素替代疗法 (ART) 是一个潜在的干预措施,以减轻这些与相关的认知缺陷.
研究的目的:
- 系统地审查和分析ART对男性下腺功能认知功能的影响.
- 调查特定领域的认知改善,假设ART的好处在所有认知领域中不是统一的.
主要方法:
- 一项全面的文献搜索确定了14项符合纳入标准的研究,截至2024年10月.
- 使用随机效应模型的元分析评估了整体和特定领域的认知结果 (记忆,注意力,执行功能,视觉空间能力).
- 发表偏差和研究异质性是使用既有统计方法来评估的.
主要成果:
- ART 显示出统计学上显著的,特定领域的认知改善 (SMD=0.454).
- 在执行功能 (SMD=0.488) 和记忆 (SMD=0.457) 中观察到显著的益处.
- 对注意力 (SMD=0.217) 和视觉空间能力 (SMD=0.226) 进行了较小,但显著的影响.
结论:
- 在男性中,ART显著增强了男性的执行功能和记忆力.
- ART对注意力和视觉空间能力的影响不那么大,表明具有特定领域的影响.
- 需要进一步的研究来优化ART协议并评估长期的认知结果,考虑到研究异质性和出版偏差.
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