唐氏综合征的印度儿童头部周长百分位数
Harvinder Kaur1, Anil Kumar Bhalla1, Inusha Panigrahi2
1Child Growth & Anthropology Unit, Department of Pediatrics, Postgraduate Institute of Medical Education & Research (PGIMER), Chandigarh, India.
Frontiers in pediatrics
|May 13, 2025
概括
这项研究为患有唐氏综合征 (DS) 的印度儿童创建了头周长 (HC) 增长图表. 这些图表显示,大多数患有DS的儿童都患有小头,强调需要专门的生长监测.
科学领域:
- 儿科 儿科 儿科
- 遗传学 遗传学 是一个
- 人类测量学 人类测量学.
背景情况:
- 准确的生长监测对于患有唐氏综合征 (DS) 的儿童至关重要.
- 现有的生长图表可能不会准确地反映印度儿童的头周长 (HC).
- 需要特定人群的参考资料来进行最佳的临床评估.
研究的目的:
- 为印度患有唐氏综合征 (DS) 的儿童构建年龄和性别特定的头周长 (HC) 增长百分位.
- 为监测该种群中HC增长提供参考标准.
- 确定印度儿童患有DS的小头症的患病率.
主要方法:
- 在24年内采用混合纵向研究设计.
- 从1,125名印度儿童中收集了2,327个HC测量,这些儿童患有核型证明的自由三发症21 (年龄小于1个月至10岁).
- 标准化的人类测量技术用于所有测量.
主要成果:
- 平均HC随着年龄的增长在DS的男孩和女孩中稳步增加.
- 患有DS的男孩表现出比患有DS的女孩显著更大的HC.
- 微头是普遍存在的,影响了59.9%的儿童; 27.2%的孩子头很小,12.9%的孩子头很小.
结论:
- 对于患有DS的印度儿童,成功地建立了特定于年龄和性别的HC增长百分位数.
- 这些生长图表对于准确的生长监测和临床管理至关重要.
- 这些发现突显了这一群体中小头症的高患病率,强调了需要专门的生长图的需要.
相关概念视频
Applications of Normal Distribution
4.9K
The normal distribution is a useful statistical tool. One of its practical applications is determining the door height after considering the normal distribution of heights of persons, such that many can pass through it easily without striking their heads. The normal distribution can also determine the probability of a person having a height less than a specific height.
The heights of 15 to 18-year-old males from Chile from 1984 to 1985 followed a normal distribution. The mean height is 172.36...
The heights of 15 to 18-year-old males from Chile from 1984 to 1985 followed a normal distribution. The mean height is 172.36...
4.9K
Karyotyping
55.5K
Overview
55.5K
Intellectual Disability
30
Intellectual disability (ID) is a neurodevelopmental condition characterized by deficits in intellectual and adaptive functioning that manifest during the developmental period. This condition encompasses challenges in reasoning, memory, problem-solving, and learning, accompanied by impairments in everyday life skills, such as communication, self-care, and social interactions. Intellectual disability affects approximately 1% of the population in the United States, impacting an estimated 5...
30
z Scores and Area Under the Curve
10.3K
z scores are the standardized values obtained after converting a normal distribution into a standard normal distribution. A z score is measured in units of the standard deviation. The z score tells you how many standard deviations the value x is above (to the right of) or below (to the left of) the mean, μ. Values of x that are larger than the mean have positive z scores, and values of x that are smaller than the mean have negative z scores. If x equals the mean, then x has a z score of...
10.3K
Meiosis I
191.7K
Meiosis is a carefully orchestrated set of cell divisions, the goal of which—in humans—is to produce haploid sperm or eggs, each containing half the number of chromosomes present in somatic cells elsewhere in the body. Meiosis I is the first such division, and involves several key steps, among them: condensation of replicated chromosomes in diploid cells; the pairing of homologous chromosomes and their exchange of information; and finally, the separation of homologous chromosomes by...
191.7K
The Bell Curve
60
The normal probability distribution, often depicted as a symmetrical, bell-shaped curve, is fundamental in statistics and the study of natural phenomena. This pattern, famously described by mathematician Carl Friedrich Gauss, shows how data points are distributed around a central mean, with most values near the average and fewer observations occurring as they deviate further from it.
This pattern applies to many human characteristics beyond intelligence, such as height. For example, if you...
This pattern applies to many human characteristics beyond intelligence, such as height. For example, if you...
60


