中年和老年中国成年人的认知功能和Cre/BW之间的关联:来自查尔斯研究的证据
Shuting Li1, Mengya Qi1, Yanxue Wang1
1Beijing Ditan Hospital, Capital Medical University, Beijing, China.
Frontiers in public health
|May 13, 2025
概括
较低的肌肉质量,以较低的肌素与体重 (Cre/BW) 比率表示,与中国成年人的认知功能较差有关. 较高的Cre/BW比率独立地预测了随着时间的推移,认知障碍的风险增加.
科学领域:
- 老年学和衰老研究研究.
- 神经科学与认知健康
- 生物标志物和健康评估
背景情况:
- 肌与体重的比率 (Cre/BW) 是用于评估肌肉质量的验证生物标志物.
- 标志着肌肉质量损失的萨尔科佩尼亚,越来越多地与老年人群的认知能力下降有关.
- 现有的研究突出了对Cre/BW和认知功能关系的进一步调查的需要.
研究的目的:
- 在一个代表性的中国成年人群中,全面分析Cre/BW与认知功能之间的关联.
- 研究Cre/BW与发展认知障碍的风险之间的纵向关系.
主要方法:
- 利用来自中国健康与退休纵向研究 (CHARLS) (2012-2018) 的纵向数据.
- 采用多变量调整的线性和逻辑回归用于横截面认知功能分析.
- 应用时间到事件分析,使用Cox比例危险模型进行纵向风险评估,控制混因素.
主要成果:
- 在Cre/BW比率和总认知功能得分之间发现了一个显著的反向关联,在多变量调整后仍然存在.
- 较低的Cre/BW比率始终与四分位数中的更好的认知表现有关.
- 较高的Cre/BW比率独立地与认知障碍风险增加有关 (HR=1.207),观察到剂量反应关系.
结论:
- 这项研究证实了Cre/BW与中国成年人的认知功能之间存在显著的反向关联.
- 较高的Cre/BW比被认为是认知障碍的独立风险因素.
- 研究结果强调了肌肉质量评估对于预测老年人群认知健康轨迹的重要性.
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