针通过调节肠道微生物群和棕酸代谢来减轻实验性自身免疫甲状腺炎
Huimin Li1, Fengjun Qi1, Dan Li1
1College of Acupuncture and Orthopedics, Hubei University of Chinese Medicine, Wuhan, China.
Frontiers in immunology
|May 13, 2025
概括
针治疗通过减少细胞亡,有效地改善了实验性自身免疫甲状腺炎的老鼠的甲状腺功能障碍. 这种治疗效果与肠道微生物群和血清代谢物的有益变化有关.
科学领域:
- 免疫学 免疫学 免疫学
- 微生物学 微生物学
- 代谢学 代谢学 代谢学
- 传统中国医药 传统中国医药
背景情况:
- 自身免疫性甲状腺炎 (AIT) 是一种与血清代谢物和肠道微生物群失调相关的慢性自身免疫性疾病.
- AIT的潜在机制涉及甲状腺毛囊上皮细胞亡.
- 针在治疗免疫相关疾病方面表现有前途,但其在AIT中的机制需要阐明.
研究的目的:
- 在试验性自身免疫甲状腺炎 (EAT) 的小鼠模型中研究针 (Acu) 的治疗机制.
- 评估肠道微生物群,血清代谢物和针治疗在EAT中的关系.
- 在AIT中确定针干预的潜在治疗点.
主要方法:
- 患有EAT的老鼠接受了针 (Acu) 或酵母 (阳性对照) 治疗六周.
- 用ELISA,HE染色,电子显微镜,TUNEL,IHC和西方斑点来评估甲状腺功能,炎症标志物和亡.
- 用16S rRNA测序和LC-MS代谢学分析了肠道微生物群和血清代谢概况.
主要成果:
- 针改善了EAT大鼠的甲状腺功能障碍和组织病理变化.
- Acu治疗增加了Bcl-2和降低了Bax,并分裂了caspase-3,表明减少了亡.
- 针调节了肠道微生物群,增加了Prevotella的丰富性,并通过调节棕酸代谢来减轻代谢障碍.
结论:
- 针可以改善甲状腺毛囊上皮细胞亡的EAT大鼠.
- 在AIT中针的治疗效果与肠道微生物群和代谢概况的调节有关.
- 在EAT中,prevotella和特定代谢物可以作为针和传统治疗的共同目标.
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