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不同的淋巴激素释放激素激活剂对IVF/ICSI-ET长期协议结果的影响:一项回顾性研究

Min Xu¹, Honglin Li¹, Yiyan Zhao¹

¹Reproductive Center, Huai'an First People's Hospital of Nanjing Medical University, Huaian, People's Republic of China.

International journal of women's health

|May 13, 2025

概括

戈塞林酸在IVF/ICSI-ET中显示出优异的妊娠结果,需要更少的淋巴激素. 虽然在统计学上不显著,相比于triptorelin酸和leuprorelin,它显示了改善生育治疗的希望.

科学领域:

生殖内分泌学和不孕症治疗.

背景情况:

激素释放激素的激素激应剂 (GnRH-a),如甲酸,甲酸和甲酸在IVF/ICSI-ET中至关重要.
有限的现实世界数据存在于不同GnRH-a配方的临床结果的比较.

研究的目的:

为了比较IVF/ICSI-ET的临床结果,在长时间的协议中,在卵泡阶段使用triptorelin酸盐,leuprorelin和goserelin酸盐.

主要方法:

这是一项对154名接受试管婴儿/ICSI-ET治疗的不孕妇女的回顾性研究.
根据GnRH-a配方,患者被划分为三个组:三重烯酸,烯酸或烯酸.
统计分析包括学生的t测试,皮尔森的千平方和费舍尔的精确测试.

主要成果:

与三烯酸 (A) 和烯酸 (B) 相比,烯酸 (C) 组在较少的日内 (9.50天) 使用明显较少的淋巴激素 (1685.94U).
戈塞林酸组表现出最高的植入率 (41.9%),临床怀孕率 (57.9%) 和活产率 (52.6%).
在这三组人群中,果烯酸也显示出最低的流产率 (9.1%).

结论:

戈塞林酸似乎在IVF/ICSI-ET中产生了有利的妊娠结果,与减少淋巴激素使用有关.
虽然趋势有利于戈塞雷林酸盐,但与托雷林酸盐和罗雷林相比,统计学意义需要进一步调查.
建议进行更大规模的试验或元分析来证实这些发现.

关键词:

这是IVF/ICSI-ET.淋巴结核激素释放激素的激动剂这就是Goserelin.莱普雷林是什么? 莱普雷林是什么?三重素三重素的使用方法

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