活微生物在慢性炎症性呼吸道疾病和抑郁症状之间起到温和作用
Wenqiang Li1, Qian He2, Jingshan Bai3
1Department of Pulmonary and Critical Care Medicine, Zigong First People's Hospital, Zigong, Sichuan, China.
Frontiers in nutrition
|May 13, 2025
概括
慢性炎症性呼吸道疾病 (CIAD) 增加了抑郁症状的风险. 饮食中的活微生物可以减轻这种风险,而较高的摄入量与CIAD患者抑郁症状的减少有关.
科学领域:
- 医学研究 医学研究
- 公共卫生 公共卫生
- 微生物组研究 微生物组研究
背景情况:
- 慢性炎症性呼吸道疾病 (CIAD) 与心理健康状况有关.
- 人们越来越认识到肠-大脑轴和微生物组在健康中的作用.
- 了解影响CIAD和抑郁症状的因素对于公共卫生至关重要.
研究的目的:
- 研究饮食中的活微生物对CIAD和抑郁症状之间的关系的影响.
- 分析CIAD和抑郁症状之间的关联.
- 探索饮食中的活微生物在调节这种关联方面的潜力.
主要方法:
- 利用了来自NHANES数据库 (2007-2020年) 的数据,其中共有23,072名参与者.
- 使用后勤回归来分析CIAD和抑郁症状关系.
- 进行子组分析并评估活微生物对CIAD患者抑郁症状的影响.
主要成果:
- CIAD与抑郁症状的风险增加有关.
- 饮食中较高的活微生物水平与CIAD患者抑郁症状风险降低相关.
- 亚组分析显示,不同的人口群体之间没有显著的相互作用效应.
结论:
- CIAD会增加患抑郁症症状的风险.
- 饮食中的活微生物似乎对CIAD-抑郁症症状关系产生负面调节.
- 饮食中大量摄入活微生物显著降低了CIAD患者抑郁症状的风险.
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