孕激素修饰的自然循环和激素替代疗法循环的比较,用于单冷母细胞母细胞移植 (COMPROSET) 中的子宫内膜制备:开放标签随机对照试验的协议
Hai-Ning Yuan1, Jing-Yan Song1,2, Zhen-Gao Sun1,2
1The First Clinical College, Shandong University of Traditional Chinese Medicine, Jinan, China.
本研究将孕激素修饰自然循环 (P4mNC) 与用于冷解胚胎移植 (FET) 的激素替代疗法 (HRT) 进行比较. 在接受试管婴儿的妇女中,P4mNC可能为HRT提供一种方便的替代方案,以提高活产率.
科学领域:
- 生殖医学 生殖医学
- 不孕症治疗 不孕症治疗
- 辅助生殖技术 辅助生殖技术
背景情况:
- 不孕症发病率正在上升,这推动了冷解胚胎移植 (FET) 技术的进步.
- 子宫内膜准备对于FET的活产率 (LBR) 至关重要,目前正在就最佳方案进行辩论.
- 与自然周期 (NC) 相比,激素替代疗法 (HRT) 周期会增加怀孕和产科并发症的风险.
研究的目的:
- 为了比较孕激素修饰自然循环 (P4mNC) 与HRT对FET结果的疗效.
- 为了确定P4mNC-FET是否在活产率方面与HRT-FET不劣.
- 评估P4mNC在辅助生殖中与HRT相比的方便性和安全性.
主要方法:
- 一个单中心,开放标签,随机对照试验 (RCT) 涉及672名接受体外受精 (IVF) 的女性.
- 有规律月经周期的参与者将随机分配到P4mNC或HRT组,进行单次冷解芽细胞移植 (FBT).
- 将使用治疗意图分析来评估活产率 (LBR) 作为主要结果.
主要成果:
- 在研究完成和数据分析后,填写本部分.
- 该研究旨在为P4mNC和HRT协议提供关于LBR的可靠数据.
- 对比分析将侧重于P4mNC与HRT的非劣势.
结论:
- 在研究完成和数据分析后,填写本部分.
- 这些发现将为临床实践提供关于FET的子宫内膜制备的信息.
- 这项研究旨在为患者提供一个更方便和潜在的更安全的FET协议.
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