患有类风湿性关节炎的男性的疲劳和相关因素:使用FACIT-F尺度的病例对照研究
Joan M Nolla1, Lidia Valencia-Muntalà1, Laura Berbel-Arcobé1
1Department of Rheumatology, IDIBELL-Hospital Universitari de Bellvitge, University of Barcelona, Barcelona, Spain.
Frontiers in medicine
|May 13, 2025
概括
疲劳在患有类风湿性关节炎 (RA) 的老年男性中更为普遍,并且与疾病活动和炎症有关. 了解这些因素可以改善男性的RA管理.
科学领域:
- 类风湿病学 类风湿病学
- 临床医学 临床医学
- 患者健康 患者健康
背景情况:
- 疲劳是患有类风湿性关节炎 (RA) 的男性常见但尚未研究的症状.
- 这项研究侧重于50岁以上的RA的西班牙男性疲劳的患病率和严重程度.
研究的目的:
- 为了调查老年西班牙男性的疲劳的患病率和严重程度,诊断出RA.
- 在这个特定的人口群体中确定与疲劳相关的因素.
主要方法:
- 一项涉及84名RA患者和102名对照者的病例控制研究 (平均年龄为71.9岁).
- 使用FACIT-F尺度评估疲劳,以及炎症标志物 (CRP,ESR),疾病活动 (DAS28,RAPID3),残疾 (HAQ) 和生活质量 (SF-12).
主要成果:
- 与对照组相比,RA患者报告的疲劳水平明显高 (FACIT-F的中位数为41.5比46.25,p<0.05).
- 疲劳与炎症标志物 (ESR,CRP) 和疾病活性 (DAS28,RAPID3) 有负相关性.
- 疲劳与SF-12的身体和心理健康成分有积极的相关性; RAPID3,SF-12和ESR是关键预测因素.
结论:
- 疲劳是RA的老年男性的一个显著的并发症.
- 疲劳与炎症,疾病活动和生活质量的降低密切相关.
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