美国成年人胰岛素抵抗与腰部疼痛风险之间的关联:一个横截面研究
Zhiqiang Que1, Dingqiang Chen2, Huirong Cai2,3
1Department of Orthopedics, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, China.
Frontiers in medicine
|May 13, 2025
概括
胰岛素抵抗是2型糖尿病的关键特征,与腰部疼痛的风险增加有关. 这项研究发现多种胰岛素抵抗指标,包括TyG-BMI和TyG-WC,始终与腰部疼痛相关.
科学领域:
- 内分泌学 在内分泌学.
- 代谢综合征是代谢综合征的一种.
- 疼痛管理 疼痛管理
背景情况:
- 胰岛素抵抗是2型糖尿病的一个标志.
- 2型糖尿病与腰部疼痛有关,但与胰岛素抵抗的直接联系尚未得到充分探索.
- 这项研究调查了多种胰岛素抵抗指标及其与腰部疼痛的关联.
研究的目的:
- 为了全面调查胰岛素抵抗和腰部疼痛之间的联系.
- 为了评估这种关系,使用各种胰岛素抵抗指数:HOMA-IR,TyG,TyG-BMI,TyG-WC和TyG-WtHR.
主要方法:
- 使用了来自国家健康和营养检查调查 (NHANES) 的数据.
- 采用多变量逻辑回归来分析胰岛素抵抗指标与腰部疼痛之间的关联.
- 进行分层分析以评估观察到的关联的稳定性.
主要成果:
- 总共分析了6,126名参与者 (2,469名患有腰部疼痛).
- 所有五个胰岛素抵抗指数 (HOMA-IR,TyG,TyG-BMI,TyG-WC,TyG-WtHR) 在完全的协变性调整后都显示出与腰部疼痛有显著的关联.
- TyG-BMI,TyG-WC和TyG-WtHR显示出与腰部疼痛之间特别稳定的相关性.
结论:
- 胰岛素抵抗与增加腰部疼痛的风险显著相关.
- 发现HOMA-IR,TyG,TyG-WC,TyG-BMI和TyG-WtHR与腰部疼痛之间的关联是稳定的.
- TyG-BMI,TyG-WC和TyG-WtHR似乎比单独的TyG更强有力的指标.
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