潘特拉辛3表达在败血性心肌病中的诊断效用:从前性观察性研究中得出的发现
Na Cui1,2, Xiao-Wei Lv2, Teng-Hao Shao2
1Department of Critical Care Medicine, The Fourth Affiliated Hospital of Hebei Medical University, Shijiazhuang, 050010, People's Republic of China.
Journal of inflammation research
|May 13, 2025
概括
败血性休克患者中德素3 (PTX3) 水平升高表明败血性心肌病 (SCM) 的风险较高. PTX3显示出作为早期SCM诊断的生物标志物的潜力.
科学领域:
- 生物化学 生物化学
- 心脏病学 心脏病学
- 关键护理医学 关键护理医学
背景情况:
- 败血性心肌病 (SCM) 是败血症的一个严重并发症.
- 早期诊断SCM对于患者的治疗结果至关重要.
- 原素3 (PTX3) 是一种炎症标记物,在心血管疾病中具有潜在的作用.
研究的目的:
- 在患有败血性心肌病 (SCM) 的患者中调查Pentraxin 3 (PTX3) 表达.
- 评估PTX3用于预测SCM的诊断潜力.
主要方法:
- 对122名败血症休克患者进行前性观察性研究.
- 血PTX3度的测量在入院和第3天和第7天.
- 在SCM和非SCM组之间比较PTX3水平.
- 与SCM临床指标和风险因素的相关性分析.
- 对PTX3的预测性能进行接收机操作特征 (ROC) 曲线分析.
主要成果:
- 在24.6%的患者中发现了SCM.
- 在SCM组的血PTX3水平在入院时和第3天显著更高 (p < 0.001).
- PTX3与前素,乳酸盐,热素I,SOFA和APACHE II分数相关联.
- 升高的PTX3独立预测SCM的发展.
- 在预测SCM时,ROC分析显示PTX3的AUC为0.784.
结论:
- 在SCM患者中,血PTX3度明显升高.
- PTX3显示出作为SCM早期诊断的可靠生物标志物的潜力.
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