芬在IgA脏病中的有效性和安全性:一项多中心观察性研究
Qiao-Rui Wang1, Longlong Wu1, Jian Huang2
1Department of Nephrology, Center for Regeneration and Aging Medicine, the Fourth Affiliated Hospital of School of Medicine and International School of Medicine, International Institutes of Medicine, Zhejiang University, Yiwu, Zhejiang, China.
Clinical kidney journal
|May 13, 2025
概括
费内伦在加入标准护理时,显著减少了免疫球蛋白脏病 (IgAN) 患者的蛋白尿症. 这种治疗显示出良好的安全性,类似于单独使用标准护理.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學.
- 药理学 药理学是指药理学的学科.
- 内部医学 内部医学
背景情况:
- 免疫球蛋白A脏病 (IgAN) 是慢性脏病的常见原因.
- 芬龙是一种非类固醇矿物质皮质类受体对抗剂,在2型糖尿病脏病中显示出对脏的益处.
- 目前,关于芬雷在IGAN中的疗效和安全性的证据有限.
研究的目的:
- 在IGAN患者中评估长达6个月的芬瑞治疗的安全性和有效性.
- 为了评估费内伦对Igan患者蛋白尿症减少的影响.
主要方法:
- 这是一项回顾性队列研究,涉及三家医院的178名Igan患者.
- 患者接受了标准的支持性护理,分为氨酸- ангиотензин系统抑制剂 (RASI) 和RASI + 芬龙组.
- 主要结局:在6个月内,蛋白与肌素比率 (PCR) 的百分比下降.
主要成果:
- 与RASI组 (32.5%) 相比,RASI + finerenone组显示出更大的PCR减少 (45.1%) (P = .013).与RASI组相比,RASI组显示出更大的PCR减少 (45.1%).
- 芬龙组中更多的患者实现了PCR<0.3g/g (37.1%对20.2%).
- 没有观察到无法控制的高血症或重大不良事件;eGFR变化没有统计学意义.
结论:
- 当添加到优化的RASI疗法时,芬瑞可显著减少Igan患者的蛋白尿症.
- 在这个队列中,芬的安全性概况与之前的研究结果一致.
- 进一步的长期研究是有必要的,以评估结局.
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