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适应COVID-19疫苗的Omicron XBB 1.5的比较有效性:一个系统的文献综述和网络元分析

Kyle Fahrbach¹, Allie Cichewicz¹, Haitao Chu²

¹Evidence Synthesis, Evidera Inc., Wilmington, NC, USA.

Expert review of vaccines

|May 13, 2025

概括

适应OMICRON的COVID-19疫苗,特别是XBB.1.5mRNA配方,在成人中对XBB相关的感染和住院治疗的有效性相似. 老年人可能会从BNT162b2 (Comirnaty) 中获得更大的好处.

科学领域:

免疫学免疫学免疫学
疫苗学疫苗学疫苗学
公共卫生公共卫生

背景情况:

对于COVID-19疫苗,特别是适应Omicron的版本的比较有效性数据是有限的.
评估更新疫苗的实际有效性对于公共卫生战略至关重要.

研究的目的:

进行针对适应Omicron的COVID-19疫苗的有效性研究的系统审查和网络元分析 (NMA) 可行性评估.
为了比较不同适应Omicron的疫苗配方的有效性.

主要方法:

在MEDLINE和Embase数据库中进行了系统的搜索,直到2025年2月.
网络元分析 (NMA) 针对25项研究的调整疫苗有效性 (VE) 数据进行,其中16项是XBB配方.
贝叶斯随机效应模型用于NMA,并对常见的比较器和效果修饰器进行可行性评估.

主要成果:

该审查包括25项针对Omicron适应的COVID-19疫苗的研究,其中16项专注于XBB配方 (8项在NMA中),涉及2990万参与者.
BNT162b2 (Comirnaty) 拥有最广泛的证据基础.
对XBB.1.5适应的BNT162b2和mRNA-1273 (Spikevax) 的比较显示,在成人中对XBB相关的住院治疗,感染和医疗护理访问的有效性相似. 对与XBB相关的住院治疗的有效性有利于老年人中的BNT162b2.

结论:

观察性研究的网络元分析支持XBB.1.5-适应的mRNA COVID-19疫苗的有效性.
限制包括关于效果修饰器和稀疏证据网络的假设.

关键词:

BNT162b2b2 在线阅读在 COVID-19 疫情中,这就是SARS-CoV-2病毒.间接比较间接比较间接比较它们是mRNARNA.mRNA-1273 的使用情况.网络元分析网络元分析系统性审查系统性审查

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