使用尿液和阴道自取样本对临床医生收集的样本进行宫癌查的准确性分析:系统性审查和元分析
Dong-Mei Li1,2, Qing-Yu Liu1,2, Shao-Long Xue1,2
1Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, Chengdu, China.
概括
阴道自取样显示了宫癌查的强大诊断性能,优于尿液自取样. 这两种方法在检测显著的宫病变方面都显示出相似的灵敏度.
科学领域:
- 妇科 妇科 妇科 妇科
- 在瘤学瘤学.
- 诊断医学 诊断医学
背景情况:
- 宫癌查对于早期发现和预防至关重要.
- 目前的查方法依赖于临床医生收集的样本,这对一些人来说可能是一个障碍.
- 自取样方法提供了一个潜在的替代方案,以提高查的可访问性和吸收率.
研究的目的:
- 为了比较阴道自取样本,尿液自取样本和临床医生用于宫癌查的诊断性能.
- 评估不同采样方法在检测宫异常时的灵敏度,特异性和AUC.
主要方法:
- 按照PRISMA 2020指南进行系统审查和元分析.
- 搜索了主要的数据库,包括PubMed,科克兰图书馆,科学网和Embase.
- 采用STATA 18.0.0的组合诊断性能指标 (灵敏度,特异性,AUC)
主要成果:
- 包括15项研究与3665名参与者,所有与异常查结果.
- 阴道和尿液自取样显示了0.88的综合灵敏度和0.81的特异性 (AUC=0.92).
- 与尿液自取样 (0.88) 相比,阴道自取样显示高风险HPV检测的AUC (0.93) 较高. 这两种方法对>CIN2病变的敏感性相似.
结论:
- 阴道和尿液自取样本对宫癌查中的HPV检测有希望.
- 与尿液自取样相比,阴道自取样显示出更高的诊断性能.
- 这两种自取样方法在检测高度子宫病变 (>CIN2) 时具有相似的灵敏度.
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