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对于关节炎药物输送的纳米晶体的最新进展

Luca Morici^1,2, Olivier Jordan^1,2, Eric Allémann^1,2

¹School of Pharmaceutical Sciences, University of Geneva, Geneva, Switzerland.

Expert opinion on drug delivery

|May 13, 2025

概括

纳米晶体为关节炎治疗提供了有前途的解决方案,改善了对骨关节炎和类风湿性关节炎的药物输送. 这些先进的配方旨在提供超出症状缓解的疾病修饰.

科学领域:

纳米医学是一种纳米医学.
生物材料科学生物材料科学
药物输送系统药物输送系统

背景情况:

全球有超过5亿人患有关节炎,目前的骨关节炎 (OA) 和类风湿性关节炎 (RA) 治疗方法仅提供息性症状缓解.
没有FDA或EMA批准的修改疾病的OA药物 (DMOADs) 可以恢复关节功能或再生软骨.
新型DMOADs和疾病修饰性抗风湿药物 (DMARDs) 的水溶性差阻碍了临床进展.

研究的目的:

审查纳米晶体 (NC) 药物输送系统对关节炎的最新进展.
突出NCs在克服与难溶性关节炎药物相关的挑战方面的潜力.
探索新的关节内DMOADs和软骨向策略,以加强OA管理.

主要方法:

在过去5年内发表的论文和评论的文献综述.
专注于传统的纳米悬浮,透皮微针和关节内NC-in-microparticle配方.
对各种输送系统,输送途径和关节炎类型的NC多功能性的分析.

主要成果:

纳米晶体 (NCs) 和纳米悬浮体在关节炎中展示了各种药物输送应用的多功能性.
作为NC-in-microparticles配制的关节内DMOADs显示了延长药物释放的潜力.
国药提供了一种可行的策略,以改善水溶性较差的关节炎治疗药物的交付.

结论:

纳米晶体技术为开发有效的疾病修饰性关节炎治疗提供了重大机会.
关节内路线,结合软骨向或刺激响应的水凝,增强了OA的治疗潜力.
国家治疗中心为推进关节炎护理提供了一个有前途的平台,超出目前的息措施.

关键词:

纳米晶体是一种纳米晶体.药物输送是药物输送的过程.在关节内,关节内的.微针是一种微针.这些微粒是微粒.纳米悬浮是一种悬浮.骨关节炎是一种关节炎.类风湿性关节炎类风湿性关节炎

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