开发IBD结果效应尺寸值,以告知研究,指导方针和临床决策
Morris Gordon1, Nader Shaban2, Vasiliki Sinopoulou1
1Biomedical Evidence Synthesis and Translation, University of Central Lancashire, Lancashire, Preston, United Kingdom.
Inflammatory bowel diseases
|May 13, 2025
概括
这项研究确定了炎症性肠病 (IBD) 临床试验的共识结果值. 这些门将提高解释结果的一致性,并帮助克罗恩病和性结肠炎患者的共同决策.
科学领域:
- 胃肠病学 胃肠病学
- 临床试验设计 临床试验设计
- 基于证据的医学基于证据的医学.
背景情况:
- 在炎症性肠病 (IBD) 试验中,临床结果的解释有所不同,可能导致护理不平等.
- 格雷德方法为制定一致的指导方针提供了一个框架,但其在IBD中的应用是新的.
- 这项研究解决了IBD研究和实践中标准化结果值的需求.
研究的目的:
- 制定第一个关于克罗恩病和性结肠炎的结局值的国际共识.
- 确定IBD关键临床试验结果的有意义的效果大小.
- 促进对临床试验结果的一致解释,支持共享决策.
主要方法:
- 采用了涉及131名临床利益相关者的双相Delphi方法.
- 一项在线调查评估了对IBD结果的小,中等和大效应大小的看法.
- 欧洲和北美的国际三角测量确保了数据集的有效性.
主要成果:
- 临床缓解和严重不良事件是克罗恩病的关键; 性结肠炎的临床和内镜缓解.
- 对于临床缓解,内镜缓解和严重不良事件,定义了小,中等和大效应的共识值.
- 克罗恩病和性结肠炎之间没有发现结果感知方面的显著差异.
结论:
- 这项研究为IBD的结果大小值提供了第一个共识.
- 这些门已纳入2024年英国胃肠病学会IBD指南.
- 建议研究设计人员和临床医生将这些发现用于与患者共享决策.
相关概念视频
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
246
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
246
Inflammatory Bowel Disease IV: Pharmacological Management
80
Upon diagnosis, managing Inflammatory Bowel Disease (IBD) involves addressing several crucial aspects. The primary goals include resting the bowel, correcting malnutrition, and providing symptomatic relief. Resting the bowel may consist of medications to reduce inflammation and promote healing. Correcting malnutrition is essential, often requiring dietary adjustments and nutritional supplements. Symptomatic relief aims to ease pain, diarrhea, and other discomforts in IBD.
Pharmacologic...
Pharmacologic...
80
Inflammatory Bowel Disease II: Crohn's Disease
129
Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
129
Inflammatory Bowel Disease I: Ulcerative Colitis
98
Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
98
Irritable Bowel Syndrome II: Clinical Features and Diagnostic Evaluation
98
Irritable Bowel Syndrome II: Clinical Features and Diagnostic Evaluation
Irritable Bowel Syndrome (IBS) is classified into subtypes based on the predominant bowel habits as determined by the Bristol Stool Form Scale (BSFS). The subtypes are:
Irritable Bowel Syndrome (IBS) is classified into subtypes based on the predominant bowel habits as determined by the Bristol Stool Form Scale (BSFS). The subtypes are:
98
Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches
106
Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
106


