减少便尼古丁胺和增加细菌尼古丁胺酶基因表达在性结肠炎患者
Keiya Aoyama1, Ryodai Yamamura2, Takehiko Katsurada1
1Department of Gastroenterology and Hepatology, Hokkaido University Hospital, Sapporo, Hokkaido, Japan.
Inflammatory bowel diseases
|May 13, 2025
概括
性结肠炎患者的便维生素B3含量较低,肠道细菌发生变化. 肠道功能失调可能会降低维生素B3的代谢,这表明补充是性结肠炎的潜在治疗方法.
科学领域:
- 胃肠病学 胃肠病学
- 微生物组研究的研究.
- 代谢学 代谢学 代谢学
背景情况:
- 性结肠炎 (UC) 与肠道微生物群有关,对肠道健康和炎症控制至关重要.
- 维生素B3 (尼古丁胺) 显示出改善UC病变的潜力.
- 肠道微生物群代谢物,包括维生素B3,在缓解肠道炎症方面发挥作用.
研究的目的:
- 为了比较UC患者和非UC患者之间的便维生素B3水平和肠道微生物群组成.
- 在UC中研究肠道微生物群和维生素B3代谢之间的关系.
主要方法:
- 分析了71名UC患者和72名非UC对照者的便样本.
- 毛细管电泳飞行时间质谱法用于代谢物分析.
- 16S rRNA基因测序确定了肠道微生物群的组成,并对混因素进行了统计调整.
主要成果:
- 患有UC的患者便中尼古丁胺 (维生素B3) 含量和肠道微生物α多样性显著降低.
- 在UC患者中,特定的细菌系 (例如Treponema,Fusicatenibacter) 减少,而其他细菌系 (例如Sellimonas,Fournierella) 增加.
- 在UC患者中观察到Sellimonas丰度和尼古丁胺水平之间的负相关性,以及UC组中尼古丁胺酶的表达更高.
结论:
- 在UC患者的肠道微生物群失调与维生素B3代谢减少有关.
- 恢复维生素B3代谢途径为性结肠炎提供了一个潜在的新疗法策略.
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