治疗阿尔茨海默病的中国传统药物:当前知识,临床应用和未来方向
Yu Deng1,2, Chaojun Chen3, Hongtao Li4
1Guangzhou University of Chinese Medicine, Guangzhou 510006, Guangdong, China.
Current topics in medicinal chemistry
|May 13, 2025
概括
传统中医 (TCM) 在预防和治疗阿尔茨海默病 (AD) 方面表现有前途. 这篇评论探讨了TCM的草药,化合物和配方,为未来的AD研究和产品开发提供了基础.
科学领域:
- 神经科学是一个神经科学.
- 药理学 药理学是指药理学的学科.
- 综合医学是一个整体的医学.
背景情况:
- 阿尔茨海默病 (AD) 是一种主要的神经退行性疾病,影响着全球人口老龄化.
- 阿尔茨海默病的复杂发病因仍然不完全理解,需要新的治疗策略.
- 传统中国医学 (TCM) 已成为阿尔茨海默病的潜在治疗途径.
研究的目的:
- 系统地审查过去20年来TCM对阿尔茨海默病的预防和治疗潜力的文献.
- 评估对单草药制剂,生物活性成分和AD的TCM复合配方的研究.
- 探索TCM抗老年症作用背后的作用机制.
主要方法:
- 对国际和国内数据库 (PubMed,Medline,Cochrane图书馆,CNKI,SinoMed,Wanfang,VIP期刊集成平台) 进行了全面的文献审查.
- 分析的重点是三种中医疗类别: tonifying 草药, 血液激活/消除静止的药物,以及孔径开放/溶解/精神稳定物质.
- 综合了TCM的疗效,生物活性化合物和针对AD的拟议机制的综合发现.
主要成果:
- 确定了多个TCM途径,点和化合物,证明了AD的预防和治疗潜力.
- 详细介绍了在处理AD病理方面的特定TCM类别的应用.
- 突出了用于AD管理的TCM中使用的各种生物活性成分和配方.
结论:
- 传统医学为管理阿尔茨海默病提供了多方面的方法,得到了广泛的研究支持.
- 本综述为在AD治疗中应用TCM提供了一个理论框架.
- 这些发现为未来的药理学研究和开发基于TCM的AD的健康产品提供了参考.
更多相关视频
08:27Establishment of a Valuable Mimic of Alzheimer's Disease in Rat Animal Model by Intracerebroventricular Injection of Composited Amyloid Beta Protein
Published on: July 29, 2018
11.8K
07:58Behavioral and Network Pharmacology-Based Analyses for the Traditional Mongolian Medicine Zadi-5 in a Rat Model of Depression
Published on: February 24, 2023
432
相关概念视频
01:22Alzheimer's Disease: Treatment
128
Alzheimer's Disease (AD), a neurodegenerative disorder, is pathologically identified by amyloid plaques and neurofibrillary tangles composed of tau protein. AD pharmacotherapy aims to manage cognitive symptoms, delay disease progression, and treat behavioral symptoms. The treatment is primarily symptomatic and palliative, with no definitive disease-modifying therapy available. Cholinesterase inhibitors, including donepezil (Aricept), rivastigmine (Exelon), and galantamine (Razadyne), are...
128
01:26Alzheimer's Disease: Overview
328
Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
328
01:30Cognitive Enhancers: Cholinesterase Inhibitors and NMDA Receptor Antagonists
85
Cognitive enhancers, also known as "smart drugs," are substances used to enhance memory, mental alertness, and concentration. These can be natural or synthetic and improve cognition in conditions like Alzheimer's disease (AD) and other neurodegenerative diseases. Some common examples include caffeine, amphetamines, methylphenidate, modafinil, arecoline, donepezil, vortioxetine, and piracetam. These enhancers work on the principle of synaptic plasticity and altered circuit function.
85
01:30Dementia
73
Dementia is a collective term for cognitive disorders primarily affecting memory, thinking, and reasoning. It is not a specific disease but a syndrome, with Alzheimer's disease being the most common cause, accounting for approximately 60-80% of cases. Other types include vascular dementia, Lewy body dementia, and frontotemporal dementia. Dementia affects millions worldwide, particularly older adults, though it is not a normal part of aging.
The progression of dementia is generally gradual....
The progression of dementia is generally gradual....
73
01:23Role of Neurotransmitters in Memory
318
Neurotransmitters are integral to the brain's communication system, enabling neurons to transmit signals across synapses. This chemical exchange underpins various cognitive functions, including memory processes. The role of neurotransmitters in memory is multifaceted, influencing the encoding, consolidation, and retrieval of memories through their action on different neural circuits.
Glutamate and Synaptic Plasticity
Glutamate, the brain's main excitatory neurotransmitter, is...
Glutamate and Synaptic Plasticity
Glutamate, the brain's main excitatory neurotransmitter, is...
318