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Updated: May 23, 2025

Non-fluoroscopic Catheter Tracking for Fluoroscopy Reduction in Interventional Electrophysiology

Non-fluoroscopic Catheter Tracking for Fluoroscopy Reduction in Interventional Electrophysiology

Published on: May 26, 2015

功能化的干预系统用于in Situ血液细胞捕获.

Ying Yu¹, Yuan Cheng², Shiwei Xu¹

¹College of Engineering and Applied Sciences, MOE Key Laboratory of High-Performance Polymer Materials and Technology, Nanjing University, Nanjing 210023, China.

ACS applied materials & interfaces

|May 13, 2025

概括

此摘要是机器生成的。

一种新的在位血液细胞捕获 (FISHC) 系统使用功能化的线直接从母体血液中分离胎儿核红细胞 (FNRBCs). 这种微侵袭性技术推进了非侵袭性产前诊断 (NIPD) 和液体活检应用.

关键词:

抗体结合的抗体结合胎儿核化的红血细胞.非侵入性的产前诊断.周围血液周围血液经过表面修改的导线.

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Last Updated: May 23, 2025

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科学领域:

生物医学工程生物医学工程
遗传学是一个遗传学.
产科产科产科产科产科

背景情况:

使用胎儿细胞的非侵入性产前诊断 (NIPD) 比侵入性方法更安全,但由于胎儿核化红细胞 (FNRBC) 数量较低和隔离效率低下而受到阻碍.
目前的技术需要抽血和活体处理,这限制了实际应用.

研究的目的:

开发和验证一种功能化的干预系统,用于直接从外围血液中在现场捕获血液细胞 (FISHC).
为了实现对NIPD的胎儿细胞的有效和最少侵入性检索.

主要方法:

开发了一种使用固定FNRBC特异性抗体的carboxybetaine methacrylate (CBMA) 功能化的医疗线.
FISHC系统的设计是为了在生理条件下直接从外围血液中在现场捕获细胞.
在孕模型中进行了体内验证.

主要成果:

FISHC系统证明了高特异性捕获FNRBCs.
在怀孕子模型中证实了高效和最少侵入性的胎儿细胞检索的可行性.
该系统消除了抽血和体外处理的需要.

结论:

在基于细胞的NIPD中,FISHC提供了一个范式的转变,通过允许直接,in situ的胎儿细胞捕获.
这项技术对改善NIPD和扩展到其他应用,如循环瘤细胞检测和实时液体活检,具有显著的前景.