在艾滋病毒感染者和未感染者中使用大麻使用障碍
Journal of addiction medicine
|May 13, 2025
概括
在所有群体中,大麻使用障碍 (CUD) 诊断显著增加,特别是在老年人和艾滋病毒感染者 (PLWH) 中. 这一趋势凸显了在这些人群中对CUD进行更好的查和治疗的需要.
科学领域:
- 公共卫生 公共卫生
- 流行病学 流行病学
- 成 药物 药物 药物 药物
背景情况:
- 美国老龄化人口越来越多地使用大麻.
- 艾滋病毒感染者 (PLWH) 是一个老龄化的人群,大麻使用率高于平均水平.
研究的目的:
- 检查2000年至2022年大麻使用障碍 (CUD) 诊断的趋势.
- 根据年龄,种族/种族,性别,并发症和艾滋病毒状况分析CUD诊断.
主要方法:
- 在"退伍军人老龄化队列研究-HIV (2000-2022) "中分析了185372名个人 (PLWH和没有艾滋病毒的人) 的电子健康记录.
- 计算了每年CUD诊断率,并使用图形和多变量物流模型检查了趋势.
主要成果:
- 在所有子组中,大麻使用障碍 (CUD) 增加,在PLWH (OR=1.14) 中的比例始终更高.
- 65岁及以上的个人在CUD诊断中表现出最显著的相对增加.
- 在PLWH (n=58,959) 和没有艾滋病毒的人群 (n=126,413) 之间,人口统计数据是可比的.
结论:
- 随着时间的推移,大麻使用障碍 (CUD) 的诊断急剧增加,特别是在艾滋病毒感染者 (PLWH) 和老年人中.
- 由于潜在的药物相互作用,老年PLWH和多种并发症患者中CUD的增加令人担忧.
- 迫切需要进行普遍查,先进的治疗选择,以及进一步研究大麻使用模式和PLWH和没有艾滋病毒的人群的结果.
更多相关视频
相关概念视频
Pulmonary Tuberculosis I
208
Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
208
Sexually Transmitted Infections
205
Sexually transmitted infections (STIs) are diseases transmitted primarily through unsafe sexual interactions. Bacteria, viruses, or parasites cause them and can result in severe health complications if untreated.ChlamydiaThe bacterium Chlamydia trachomatis is responsible for the disease Chlamydia, the most common STI in the United States. This peculiar pathogen requires human cells to reproduce, residing intracellularly. The initial infection often goes unnoticed because it typically does not...
205
Substance Use Disorders Affecting Sleep
150
Substance use disorders involve a pattern of using drugs more extensively than intended and continuing use despite harmful consequences. This includes legal substances like alcohol and nicotine, as well as illegal drugs. These disorders often involve both physical and psychological dependence, reflecting compulsive use of substances that significantly alter thoughts, feelings, and behaviors, contributing to a major public health issue.
Understanding the concepts of physical dependence,...
Understanding the concepts of physical dependence,...
150
Retrovirus Life Cycles
45.4K
Retroviruses have a single-stranded RNA genome that undergoes a special form of replication. Once the retrovirus has entered the host cell, an enzyme called reverse transcriptase synthesizes double-stranded DNA from the retroviral RNA genome. This DNA copy of the genome is then integrated into the host’s genome inside the nucleus via an enzyme called integrase. Consequently, the retroviral genome is transcribed into RNA whenever the host’s genome is transcribed, allowing the...
45.4K
CNS Stimulants: Cocaine, Amphetamines and Cannabinoids
136
CNS stimulants, such as cocaine, amphetamines, and cannabinoids, have varying structures and mechanisms of action that lead to different therapeutic effects and side effects. Cocaine, with its molecular formula C17H21NO4, is a tropane alkaloid and a tertiary amino compound. It has two chemical forms: the hydrochloride salt and the "freebase." The former is in powder form, while the latter involves removing the hydrochloride salt to create a form that can be smoked. Cocaine exerts its...
136
Chemotherapy-Induced Nausea and Vomiting: Cannabinoids
190
Tetrahydrocannabinol (THC) is a phytocannabinoid that primarily interacts with the CB1 receptor, a type of G protein-coupled receptor (GPCR) predominantly in and around the chemoreceptor trigger zone (CTZ) and emetic center. THC also blocks the serotonin receptor activity in the dorsal vagal complex (DVC) by inhibiting serotonin release. THC exerts its anti-emetic effects through these interactions, which are beneficial for patients undergoing chemotherapy.
Two synthetic agonists of THC,...
Two synthetic agonists of THC,...
190


