肝纤维化标志物FIB-4与基于人口的队列研究中的肝脏和肝外恶性瘤风险有关
Shira Zelber-Sagi1, Yochai Schonmann2,3, Galit Weinstein1
1Faculty of Social Welfare and Health Sciences, School of Public Health, University of Haifa, Haifa, Israel.
概括
先进的肝纤维化,由纤维化-4分数表明,显著增加患各种癌症的风险,包括肝脏和胆道恶性瘤. 这一发现表明纤维化标志物可以识别癌症监测的高风险个体.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 在瘤学瘤学.
- 流行病学 流行病学
背景情况:
- 代谢功能障碍相关的脂肪性肝病 (MASLD) 与肝外癌症有关.
- 肝纤维化在肝癌发展中的具体作用尚不清楚.
- 这项研究调查了肝纤维化标志物与癌症发病率之间的长期关联.
研究的目的:
- 评估肝纤维化标志物与肝脏和肝外恶性瘤发病率之间的长期关联.
- 为了确定肝纤维化是否是癌症发展的独立风险因素.
- 评估肝纤维化在识别癌症高风险个体中的预测价值.
主要方法:
- 对763,752名成年卫生服务人员进行了回顾性队列研究.
- 随访期为14.67年,不包括以前患有肝病或恶性瘤的人.
- 从常规实验室评估的纤维化-4 (FIB-4) 评分;高级纤维化被定义为FIB-4 ≥2.67. 用于分析的多变量考克斯回归.
主要成果:
- 晚期纤维化 (FIB-4 ≥2.67) 与16%的整体恶性瘤风险增加有关 (HR=1.16).
- 这种关联在特定年龄的FIB-4切断值 (HR=1.40) 和在患有MASLD的个体 (HR=1.43) 中更为强烈.
- 不明确的纤维化和晚期纤维化都与肝癌和胆道癌症有很强的关联 (HR分别为1.41和5.66).
结论:
- 肝纤维化得分是恶性瘤发生的独立预测指标.
- 特定类型的恶性瘤,特别是肝脏和胆道癌,与肝纤维化有很强的关联.
- 肝纤维化标志物可以作为识别癌症查高风险人群的有价值指标.
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