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相关概念视频

Cancer Vaccines01:30

Cancer Vaccines

259
Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
259
Preventive Healthcare Services01:30

Preventive Healthcare Services

947
Preventive healthcare services keep people healthy via frequent check-ups, screening, and counseling. They primarily aid in disease prevention rather than treating an acute or chronic illness. Preventive treatment also keeps individuals productive and energetic, allowing them to work well into their retirement years. Examples of preventive care services include:
947
Cancer Survival Analysis01:21

Cancer Survival Analysis

303
Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
303
Rous Sarcoma Virus (RSV) and Cancer01:03

Rous Sarcoma Virus (RSV) and Cancer

4.9K
Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand  RNA genome. Its genome consists of four main open...
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Cancer-Critical Genes II: Tumor Suppressor Genes01:05

Cancer-Critical Genes II: Tumor Suppressor Genes

7.2K
Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
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Cancer-Critical Genes I: Proto-oncogenes01:33

Cancer-Critical Genes I: Proto-oncogenes

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Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
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相关实验视频

Updated: May 14, 2025

Chromogenic In Situ Hybridization as a Tool for HPV-Related Head and Neck Cancer Diagnosis
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Chromogenic In Situ Hybridization as a Tool for HPV-Related Head and Neck Cancer Diagnosis

Published on: June 14, 2019

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[HPV查覆盖范围和癌症]

Joakim Dillner1, Penelope Gray2

  • 1.

Lakartidningen
|May 13, 2025
PubMed
概括

在正常细胞学测试后,子宫癌的风险正在上升. 人类乳头瘤病毒 (HPV) 查显著降低了这种风险,突出了需要更广泛的HPV测试覆盖范围.

科学领域:

  • 妇科 妇科 妇科 妇科
  • 在瘤学瘤学.
  • 公共卫生 公共卫生

背景情况:

  • 在细胞检查结果正常后,宫癌发病率正在增加,接近一般人口的风险水平.
  • 人类乳头瘤病毒 (HPV) 检测表明,与单独细胞学相比,宫癌的发病率显著降低.
  • 在瑞典一些地区推迟实施HPV查可能会导致持续的高风险病例.

研究的目的:

  • 评估实施HPV查对宫癌发病率的影响.
  • 评估HPV测试覆盖率与区域癌症率之间的相关性.
  • 倡导增加HPV查覆盖率以控制宫癌.

主要方法:

  • 与细胞学和HPV检测结果相关的宫癌发病率数据的分析.
  • 在正常细胞检查后癌症风险的比较与阴性HPV测试.
  • 区域HPV查覆盖率与子宫癌发病率之间的相关性分析.

主要成果:

  • 在正常细胞学测试后,宫癌的发病率几乎与普通人群一样高.
  • 阴性HPV测试后,宫癌的发病率比正常细胞学测试低约7倍.
  • 区域HPV测试覆盖率从62%到89%不等,覆盖率更高与癌症发病率更低相关 (r=-0.50;p=0.022).

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RNAscope for In situ Detection of Transcriptionally Active Human Papillomavirus in Head and Neck Squamous Cell Carcinoma
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RNAscope for In situ Detection of Transcriptionally Active Human Papillomavirus in Head and Neck Squamous Cell Carcinoma

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Four-color Fluorescence Immunohistochemistry of T-cell Subpopulations in Archival Formalin-fixed, Paraffin-embedded Human Oropharyngeal Squamous Cell Carcinoma Samples
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Four-color Fluorescence Immunohistochemistry of T-cell Subpopulations in Archival Formalin-fixed, Paraffin-embedded Human Oropharyngeal Squamous Cell Carcinoma Samples

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相关实验视频

Last Updated: May 14, 2025

Chromogenic In Situ Hybridization as a Tool for HPV-Related Head and Neck Cancer Diagnosis
06:57

Chromogenic In Situ Hybridization as a Tool for HPV-Related Head and Neck Cancer Diagnosis

Published on: June 14, 2019

10.3K
RNAscope for In situ Detection of Transcriptionally Active Human Papillomavirus in Head and Neck Squamous Cell Carcinoma
10:26

RNAscope for In situ Detection of Transcriptionally Active Human Papillomavirus in Head and Neck Squamous Cell Carcinoma

Published on: March 11, 2014

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Four-color Fluorescence Immunohistochemistry of T-cell Subpopulations in Archival Formalin-fixed, Paraffin-embedded Human Oropharyngeal Squamous Cell Carcinoma Samples
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Four-color Fluorescence Immunohistochemistry of T-cell Subpopulations in Archival Formalin-fixed, Paraffin-embedded Human Oropharyngeal Squamous Cell Carcinoma Samples

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结论:

  • 仅仅正常细胞学不足以进行充分的宫癌风险评估.
  • 广泛的HPV查对于减少宫癌发病率至关重要.
  • 建议紧急努力增加HPV查覆盖率,以有效控制宫癌.