胃肠道动力不良,自主功能和小肠道细菌过度生长在受良好控制的HIV感染者中
Jessica Robinson-Papp1, Mitali Mehta1, Bridget R Mueller1
1Icahn School of Medicine at Mount Sinai, Department of Neurology, New York, NY, USA.
The Journal of infectious diseases
|May 13, 2025
概括
艾滋病毒感染者表现出胃肠机动性的改变,自主神经病变与小肠细菌过度生长之间存在潜在联系. 需要进一步的研究来理解这些复杂的关系.
科学领域:
- 胃肠病学 胃肠病学
- 传染性疾病 传染性疾病
- 神经学 神经学
背景情况:
- 胃肠道功能障碍和微生物组变化与艾滋病毒 (PWH) 感染者的慢性炎症有关.
- 自主神经病变 (AN) 在PWH中改变胃肠机动性的作用尚不清楚.
研究的目的:
- 调查PWH中自主功能和胃肠机动性之间的关系.
- 探索改变运动性,小肠细菌过度生长 (SIBO) 和PWH的症状之间的潜在联系.
主要方法:
- 对100个PWH和89个对照进行横截面研究.
- 无线运动囊 (WMC) 用于胃肠道过境时间.
- 自主功能测试 (MCASS),SIBO呼吸测试,以及症状问卷 (PAGI-SYM,COMPASS-31).这些测试包括:
主要成果:
- 与对照组相比,PWH的胃排空速度 (GET) 更快,小肠 (SBTT) 和结肠传输时间 (CTT) 更慢.
- 周围交感功能 (MCASS运动得分) 与PWH中的SBTT相关.
- 长时间的SBTT (>6h) 与PWH中SIBO的可能性更高有关.
结论:
- 胃肠道运动在PWH中显著改变.
- 自主功能障碍可能会影响PWH中的小肠过境时间,可能会导致SIBO.
- 需要进一步的研究来澄清与艾滋病毒相关的AN,运动性,微生物组,炎症和临床结果之间的联系.
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