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线粒体DNA拷贝数的评估是白人的前列腺癌的强有力的预测因素,但不是黑人个体

Melanie K Flores¹, Jessica L Janes², Mirajul Islam³

¹University of Southern California, Los Angeles, United States.

Cancer prevention research (Philadelphia, Pa.)

|May 13, 2025

概括

白人前列腺癌患者的线粒体DNA (mtDNA) 拷贝数增加,但黑人患者没有. 黑人对照显示出更高的基线mtDNA水平,这表明PCa健康差异的作用.

科学领域:

遗传学和基因组学遗传学和基因组学
在瘤学瘤学.
生物化学生物化学

背景情况:

前列腺癌 (PCa) 不成比例地影响黑人.
线粒体DNA (mtDNA) 拷贝数的改变与线粒体功能障碍和癌症的发展有关.
在PCa中mtDNA拷贝数的作用,特别是在种族群体之间,仍然未被充分探索.

研究的目的:

调查PCa和没有PCa的患者的循环无细胞mtDNA和白细胞mtDNA复制数的种族差异.
确定mtDNA拷贝数是否可以以特定种族的方式作为PCa的预测生物标志物.

主要方法:

使用滴滴数字PCR (ddPCR) 测量血和WBC mtDNA复制数量,对199名接受活检的患者进行活检.
分析mtDNA拷贝数和PCa状态之间的关联,根据种族分层使用后勤回归.
使用曲线下面面积 (AUC) 分析对PCa的mtDNA拷贝数的预测准确性的比较.

主要成果:

白人患者的PCa病例与对照病例的mtDNA复制数显著增加,但在黑人患者中并非如此.
黑人对照表现出比白人对照更高的基线mtDNA复制数.
血和WBCmtDNA拷贝数与白人患者的PCa有显著的关联,但不是黑人患者,尽管血mtDNA显示了预测黑人男性PCa的潜力.

结论:

mtDNA拷贝数的改变与白人患者的PCa有关,但这种关联在黑人患者中不同.
种族群体之间基线mtDNA复制数的差异可能导致前列腺癌的健康差异.
mtDNA拷贝数作为PCa生物标志物具有潜力,其实用性和对健康公平的影响可能存在种族差异.

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