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重温反应性微质在创伤性脑损伤中的关键作用

Jing-Yu Zhao^1,2, Yang Zhou², Chao-Wen Zhou²

¹Department of Neurosurgery, Wuhan Hankou Hospital, Hankou Hospital Affiliated to Wuhan University of Science and Technology, Jiang`an District, Wuhan, People's Republic of China.

International journal of surgery (London, England)

|May 13, 2025

概括

创伤性脑损伤 (TBI) 涉及由微质细胞调节的神经炎症. 本综述详细介绍了微质在TBI中的作用,从损伤到修复,并探索了神经免疫干预的新治疗途径.

科学领域:

神经科学是一个神经科学.
免疫学免疫学免疫学
病理学病理学病理学

背景情况:

创伤性脑损伤 (TBI) 启动了一个复杂的神经炎症反应.
微质是TBI引起的损伤和随后的组织修复的核心.
微质激活的时间动态及其TBI后的长期影响需要进一步阐明.

研究的目的:

综合审查TBI中的微质反应,涵盖分子和细胞机制.
为了比较临床和临床前TBI模型的翻译相关性.
讨论针对TBI的微质调节的治疗策略.

主要方法:

在TBI中微质反应的分子和细胞机制的系统审查.
对临床和临床前TBI分类,病变模式和动物模型的比较分析.
评估单细胞转录组数据以识别不同的微质子群.

主要成果:

微质在TBI中起着双重作用,为损伤和恢复做出贡献.
单细胞转录组学揭示了伤害阶段的多样化微质子群,挑战了M1/M2二分法.
目前的治疗策略侧重于调节微质活动.

结论:

了解动态微质反应对于TBI管理至关重要.
像单细胞转录组学这样的先进分析提供了对微质异质性的更深入的见解.
精确向的神经免疫疗法对未来的TBI治疗具有前景.

关键词:

中枢神经系统中枢神经系统微质细胞中的微质细胞创伤性脑损伤是一种创伤性脑损伤

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Traumatic Brain Injury l: Introduction

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DefinitionTraumatic brain injury, or TBI, is a disturbance of normal brain function induced by an external mechanical force, such as a direct blow to the head or a penetrating injury. It can affect both brain structure and function, producing a wide range of clinical outcomes. TBI is a heterogeneous condition, meaning its effects may differ based on the type, location, and severity of the injury.Basis of ClassificationTBI is classified based on severity, injury mechanism, or pathophysiology. In...