在Saccharomyces cerevisiae的多细胞性实验进化过程中的历史效应
Joleen Khey1,2, Michael Travisano2,3,4
1Department of Plant and Microbial Biology, University of Minnesota, St Paul, Minnesota 55108.
概括
早期的进化变化对未来的适应有重大影响. 这项研究表明,一个群体的历史,甚至是数百代人的历史,塑造了它的适应性进化,证明了生物系统中的历史偶然性.
科学领域:
- 进化生物学是进化的生物学.
- 遗传学 是一个遗传学.
- 微生物学 微生物学
背景情况:
- 自然选择驱动了适应性进化,但结果取决于人口的遗传构成.
- 以前的进化历史影响着一个群体的遗传背景,从而影响着它的适应潜力.
研究的目的:
- 调查适应性进化中历史上随机结果的范围.
- 检查过去的进化事件如何影响酵母菌种群的后续适应.
主要方法:
- 在实验室酵母种群中,选择实验采用交替适应大小的选择实验.
- 利用遗传重组 (selfing) 来研究多细胞性再生.
- 分析进化多细胞表型的细胞架构.
主要成果:
- 基因重组从以前单细胞基因型中再生了多细胞性.
- 这些基因型在新的选择压力下迅速重新演变为多细胞性.
- 二次进化的多细胞表型表现出不同的细胞架构.
- 最早的适应性变化具有持久的进化后果,甚至超过数百代.
结论:
- 适应性进化在历史上是偶然的,早期的变化会产生持久的影响.
- 一个血统的进化历史显著地限制或指导未来的适应性路径.
- 历史偶然性在塑造进化轨迹方面发挥着至关重要的作用.
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