婴儿时期与RSV相关的儿科重症监护室入院的全部负担:一项前性国家研究 (BRICK研究)
Emily W E M Phijffer1, Joanne G Wildenbeest1, Carole N M Brouwer2
1From the Department of Paediatric Infectious Diseases and Immunology.
The Pediatric infectious disease journal
|May 13, 2025
概括
婴儿严重的呼吸道综合体病毒 (RSV) 疾病导致大量的儿科重症监护室 (PICU) 住院,许多人经历了不良事件,父母表现出创伤后应激障碍 (PTSD) 的迹象. 预防性干预可以减少这种负担.
科学领域:
- 儿科重症监护医药 儿科重症监护医药
- 传染病 传染病 传染病
- 公共卫生 公共卫生
背景情况:
- 呼吸道同胞性病毒 (RSV) 是婴儿下呼吸道感染的主要原因,显著的百分比需要儿童重症监护室 (PICU) 的入院.
- 了解RSV的全部临床影响,包括不那么明显的负担,对于评估新的预防策略至关重要.
研究的目的:
- 综合评估进入PICU的婴儿严重RSV疾病的负担.
- 为了确定临床特征,PICU住院期间的不良事件,以及婴儿RSV住院后的父母创伤后应激障碍 (PTSD).
主要方法:
- 在荷兰进行的一项全国性,前性,观察性,多中心研究.
- 包括12个月以下的婴儿与实验室确认的RSV相关的PICU入院.
- 收集了关于临床特征,不良事件和父母退院后PTSD症状的数据.
主要成果:
- 在423名婴儿中,大多数是没有并发症的满期婴儿,61.1%需要侵入性机械通风.
- 不良事件发生在11.3%的患者中,在那些使用侵入性机械通风的人群中更频繁 (91.9%与52.4%相比).
- 发生了三例死亡 (0.7%),所有这些都是患有严重并发症的婴儿;29.2%的父母报告了PTSD症状.
结论:
- 严重的RSV疾病给PICU入院以外的患者带来了巨大的负担,包括不良事件和父母的PTSD.
- 显著比例的婴儿 (75%) 在3个月以下,突出显示了RSV免疫计划的潜在影响.
- 实施RSV免疫可以大大减少婴儿严重RSV疾病的整体负担.
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