超皮耳神经神经刺激对慢性便秘的影响:一个多中心,随机对照研究
Tangyi Liu1, Zeyu Wang1, Yunling Li2
1State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, National Clinical Research Center for Digestive Diseases and Xijing Hospital of Digestive Diseases, Air Force Medical University, Xi'an, China.
United European gastroenterology journal
|May 13, 2025
概括
通过皮肤进行耳膜神经刺激 (taVNS) 对成年人慢性便秘没有显著的益处. 这项为期4周的研究发现,taVNS和假药治疗之间的反应率相似,这表明疗效有限.
科学领域:
- 胃肠病学 胃肠病学
- 神经学 神经学
- 医疗器械 医疗器械
背景情况:
- 慢性便秘影响了相当一部分成年人群,影响了他们的生活质量.
- 慢性便秘的当前治疗选择具有局限性和可变的疗效.
- 穿皮耳神经刺激 (taVNS) 是一种新兴的神经调节技术,具有潜在的治疗应用.
研究的目的:
- 评估通过皮肤进行耳耳神经刺激 (taVNS) 的疗效和安全性,作为诊断为慢性便秘的成年患者的治疗方法.
- 为了比较活跃taVNS与虚假手术在改善肠功能和相关症状方面的有效性.
主要方法:
- 采用随机对照试验设计,招募符合慢性便秘罗马IV标准的成年患者.
- 参与者被分配到活跃的taVNS或假taVNS,每天两次接受30分钟的会议,持续四周.
- 主要结局是应答率,定义为完全自发性排便和减少救援药物的使用;次要结局包括症状得分和不良事件.
主要成果:
- 该研究因在中间分析期间观察到的效率不足而提前终止.
- 四周后,taVNS组 (17%) 和假taVNS组 (19%) 的反应率相似,没有统计学上显著的差异.
- 没有报告任何严重不良事件,这表明taVNS在这个人群中具有有利的安全性.
结论:
- 四周的25赫兹taVNS在治疗成人慢性便秘方面没有表现出有效性.
- 根据研究的参数,这些发现不支持使用taVNS作为治疗这种疾病的干预措施.
- 可能需要进一步的研究来探索不同的taVNS参数或患者群体,但目前的证据不支持.
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