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来自注射器中的油微滴,含有内抗血管内皮生长因子和补充抑制剂注射
Libby Wei1, Erica Lee1, Xiaoxuan Fan2
1Department of Ophthalmology and Visual Sciences, University of Maryland School of Medicine, Baltimore, MD.
Retina (Philadelphia, Pa.)
|May 13, 2025
概括
通常使用的Becton Dickinson (BD) 聚碳酸注射器在静脉内注射时,与预填或无选项相比,在眼睛内注射了显著更多的油. 这种增加的油可以导致症状浮动,特别是粘性药物.
科学领域:
- 眼科医生 眼科 眼科
- 材料科学 材料科学 材料科学
- 生物医学工程 生物医学工程
背景情况:
- 静脉内注射对于治疗各种视网膜疾病至关重要.
- 油通常用于注射器制造中的滑剂.
- 注射药物中油的存在和数量是眼睛健康的关键问题.
研究的目的:
- 量化内内注射中的油水平.
- 为了比较不同类型的注射器 (预填,商用,滑,无) 中的油量.
- 评估注射器类型和药物粘度对油污染的影响.
主要方法:
- 患者接受了五种不同药物的标准静脉注射.
- 注射器是故意过度填充的,以保留用于分析的样本 (0.01-0.04mL).
- 使用光谱流细胞计测量测量了各种注射器类型的样本中的油含量,包括Becton Dickinson (BD) 聚碳酸和Ocuject VitreJect® (OV) 无注射器.
主要成果:
- 在所有测试的注射器中检测到油.
- 无卵巢注射器和预填拉尼比祖马布注射器的油含量最低.
- 贝克顿·迪金森 (BD) 聚碳酸注射器导致油含量显著提高,特别是在更粘的药物,如法里西马布,佩格塞塔科普兰和阿瓦辛卡帕达德佩戈尔.
- 用于制备药物的过针可能会导致油水平.
结论:
- 标准的Becton Dickinson (BD) 聚碳酸注射器将比预装或无替代品更大的油引入玻璃体.
- 玻璃体内油的增加,特别是对粘性玻璃体内药物的反复注射,可能会导致症状浮体.
- 选择注射器类型对于在静脉内药物递送期间最大限度地减少油污染至关重要.
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