患有类风湿性关节炎的患者中医疗保健的利用率,带有和没有疹,是一项追溯的行政数据链接队列研究
Mohammad Movahedi1,2, Angela Cesta1, Xiuying Li1
1Toronto General Hospital Research Insitute, University Health Network, Toronto, Ontario, Canada.
PloS one
|May 13, 2025
概括
患有黄疹类风湿性关节炎的患者经历了更高的医疗保健利用率,特别是更多的医生访问. 某些 RA 药物,如 JAK 抑制剂,与增加的死亡风险有关.
科学领域:
- 类风湿病学 类风湿病学
- 传染性疾病 传染性疾病
- 医疗保健服务研究 医疗服务研究
背景情况:
- 疹疹 (HZ) 对老年人和免疫抑制个体,包括患有类风湿性关节炎 (RA) 的人来说是一个重大问题.
- 了解RA患者与无HZ患者的医疗保健利用率 (HCU) 和死亡率差异对于患者管理至关重要.
研究的目的:
- 为了比较医疗保健利用率 (HCU) 和类风湿性关节炎 (RA) 患者的死亡率,这些患者经历过疹 (HZ) 与那些没有经历过的人相比.
- 调查疾病活动,患者报告的结果和RA药物对HCU和HZ的RA患者的死亡率的影响.
主要方法:
- 一个RA患者的临床队列 (2008-2020年) 与一个人口健康数据库联系在一起.
- 根据性别,年龄和诊断日期,HZ患者与非HZ患者进行了匹配.
- 计算了HCU的发生率 (住院治疗,急救访问,医生访问) 和死亡率,并对共变量进行了调整.
主要成果:
- 患有HZ的RA患者的住院/ED访问和死亡率较高,尽管在调整后不具有统计学意义.
- 高血压患者的医生访问量显著增加 (adj IRR 1.17).
- 使用JAK抑制剂与死亡率增加有关 (adj HR:4.73).
结论:
- 患有黄疹类风湿性关节炎的患者经历了更高的医疗保健利用率,特别是医生访问的增加.
- 疾病活动,患者报告的结果和RA药物在这个队列中没有显著影响HCU和死亡率.
- 使用JAK抑制剂需要进一步调查,因为它与HZ的RA患者的死亡率增加有关.
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