模拟HLH免疫突触揭示了IS终止,细胞因子强度和细胞死亡的关键作用

Anastasia M Frank-Kamenetskii1, Hannah Klinghoffer1, Jemy Anna Varghese1

  • 1Children's Hospital of Philadelphia and Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, United States.

Blood
|May 13, 2025
PubMed
概括

血细胞淋巴细胞炎 (HLH) 涉及免疫细胞功能障碍. 这项研究揭示了免疫突触终止受损和炎症细胞死亡对HLH病变产生贡献,提供了新的治疗点.

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