剖析挥发性有机化合物和心血管疾病之间的联系:免疫细胞介导的机制
Qi Cao1, Jiajing Liu1, Daiyao Lu1
1Department of Biochemistry and Molecular Biology, Key Laboratory of Neural and Vascular Biology, Ministry of Education, Hebei Medical University, Shijiazhuang 050017, China.
Ecotoxicology and environmental safety
|May 13, 2025
概括
尿液中特定挥发性有机化合物 (VOC) 的较高水平与心血管疾病风险增加有关,特别是在某些子组中. 单细胞驱动的炎症在这种关联中起着关键作用.
科学领域:
- 环境健康 环境健康
- 心血管疾病研究研究
- 免疫学 免疫学 免疫学
背景情况:
- 挥发性有机化合物 (VOC) 是具有已知的健康影响的环境污染物.
- 挥发性有机物与心血管疾病 (CVD) 之间的具体联系需要进一步调查.
研究的目的:
- 检查尿液中的VOC代谢物与心血管疾病风险之间的关联.
- 确定单细胞是否调解VOC和CVD之间的关系.
- 确定参与VOC暴露和免疫反应的生物途径.
主要方法:
- 分析国家健康和营养检查调查 (NHANES) 数据 (2011-2018).
- 应用三个统计模型来评估VOC代谢物与心血管疾病风险相关性.
- 调解分析以量化单细胞贡献.
- 转录组分析和路径丰富.
主要成果:
- 在尿路DHBMA,HPMMA和ATCA与心痛和冠心病风险之间发现了显著的积极关联.
- 确定了高风险子组:体重正常的成年人,中度活跃的个人,低收入和高收入人群以及目前的饮酒者.
- 单细胞相关通路解释了13.1%-112.4%的关联;NF-κB和AGE-RAGE信号通路得到了丰富.
结论:
- 尿路DHBMA,HPMMA和ATCA的升高与更高的心血管风险有关,由单细胞炎症介导.
- 正常体重,适度活跃的成年人,社会经济弱势群体和饮酒者风险增加.
- 建议制定针对室内空气质量,VOC排放和单细胞介导炎症的公共卫生战略.
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