使用/甲基酸盐聚合物的pH响应纳米颗粒的配方,以提高维生素D3的生物可用性
Harshitha Annappa1, Anand Tamatam1, Ilaiyaraja Nallamuthu1
1Nutrition, Biochemistry and Toxicology Division, Defence Institute of Bio-Defence Technology (DIBT-DRDO), Siddhartha Nagar, Mysore 570011, India.
International journal of biological macromolecules
|May 13, 2025
概括
这项研究开发了响应pH的/藻酸盐纳米颗粒,以改善维生素D3的输送. 这些纳米颗粒增强了维生素D3的稳定性,并显著增加了大鼠的生物可用性和骨矿化.
科学领域:
- 材料科学 材料科学 材料科学
- 生物技术是生物技术.
- 营养科学 营养科学
背景情况:
- 维生素D3 (Vit D3) 供应受到降解和生物可用性差的阻碍.
- 先进的封装对于有效的维生素D3补充至关重要.
- 酸/酸 (Z/SA) 具有作为疏水性维生素的载体的潜力.
研究的目的:
- 开发和评估适应pH值的/藻酸盐 (Z/SA) 纳米颗粒,以提高维生素D3 (Vit D3) 输送.
- 评估维生素D3装载纳米颗粒的稳定性,封装效率和释放特征.
- 研究开发的纳米粒子系统的in-vivo生物可用性和骨矿化效应.
主要方法:
- 纳米颗粒 (NP) 用抗溶剂技术与和酸制备.
- 描述包括SEM,FTIR,紫外线光谱和TGA用于结构和热稳定性.
- 进行了体外 (pH依赖释放) 和体外 (大鼠生物可用性,性酸酶测定) 研究.
主要成果:
- 优化的NP (<200nm,-56mV泽塔电位) 实现了77%的封装效率.
- NP表现出pH响应性行为,在pH3以上稳定,在肠道pH下持续释放.
- 实体研究显示,与自由维生素D3相比,生物可用性增加了3.4倍,骨矿化增加了1.3倍.
结论:
- 酸/酸纳米粒子是改善维生素D3稳定性和生物可用性的有效系统.
- 响应pH的性质确保了有针对性的释放和增强的吸收.
- 该系统对食品和营养药品行业的应用具有前景.
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