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阻塞性睡眠呼吸暂停与晚期糖尿病病患者的心脏结构和功能变化有关
Sebastian Nielsen1, Jakob Nyvad1, Erik Lerkevang Grove2
1Department of Renal Medicine, Aarhus University Hospital, Aarhus, Denmark.
Diabetes research and clinical practice
|May 13, 2025
概括
中度至重度的阻塞性睡眠呼吸暂停 (OSA) 与晚期糖尿病病 (DKD) 患者的心脏变化有关. 这些发现凸显了在这个脆弱人群中与OSA相关的潜在心血管风险.
科学领域:
- 心脏病学 心脏病学
- 腎臟病學 (nephrology) 是一種醫學.
- 睡眠医学 睡眠医学
背景情况:
- 阻塞性睡眠呼吸暂停 (OSA) 在2型糖尿病 (T2DM) 中很普遍.
- 在晚期糖尿病病 (DKD) 中OSA对心脏的影响尚不清楚.
研究的目的:
- 为了研究中度至重度的OSA与T2DM晚期DKD患者的心脏结构和功能之间的关联.
主要方法:
- 患有晚期DKD (eGFR <60mL/min/1.73m2和白膜尿) 的患者使用呼吸暂停-呼吸暂停指数 (AHI) 评估OSA.
- 评估心脏参数通过 transthoracic 心脏回声学.
- 39名没有OSA (AHI <5) 的患者与34名中度至重度OSA (AHI ≥15) 的患者进行了比较.
主要成果:
- 与没有OSA患者相比,中度至重度OSA患者的左心室体积指数 (LAVI),左心室质量指数 (LVMI) 和右心室直径 (RVD) 显著提高.
- 在中度至重度OSA患者中,全球纵向应变 (GLS) 减少.
- 多变量分析证实了OSA与LAVI,LVMI,RVD增加和GLS减少的相关性,独立于其他因素.
结论:
- 中度至重度的OSA与高级DKD中的心脏缩和腔室扩张有关.
- 这些心脏变化可能导致T2DM患有DKD和OSA的患者心血管风险增加.
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