在患有炎症性肠道疾病的患者中发生疹感染
Dong Hyun Kim1, Sang-Bum Kang2
1Department of Internal Medicine, Chonnam National University Medical School, Gwangju, Korea.
The Korean journal of internal medicine
|May 13, 2025
概括
患有炎症性肠病 (IBD) 的患者有较高的疹子风险. 建议用Shingrix接种疫苗,特别是那些服用免疫抑制剂的人,以防止HZ的重新激活.
科学领域:
- 免疫学 免疫学 免疫学
- 胃肠病学 胃肠病学
- 疫苗学 疫苗学 疫苗学
背景情况:
- 患有炎症性肠病 (IBD) 的患者因免疫抑制疗法 (皮质类固醇,硫素,生物制剂) 而面临疹 (HZ) 的风险增加.
- 尽管疹病毒重新激活的风险增加,但这种患者群体中对疹病毒的疫苗接种率仍然低于最佳水平.
研究的目的:
- 审查疹疫苗在患有炎症性肠道疾病的患者中的重要性.
- 为了突出与Zostavax相比,Shingrix在免疫受损个体中的有效性和安全性.
- 讨论量身定制的疫苗接种策略和对特定人群进行进一步研究的需要.
主要方法:
- 文献综述侧重于疹子风险,疫苗接种和炎症性肠病患者的特定疗法.
- 对疫苗有效性和安全性数据的分析,特别是针对免疫受损人群中的Shingrix.
- 检查影响HZ发病率和疫苗接种建议的因素.
主要成果:
- 在免疫功能低下的人群中,Shingrix表现出高效率 (>90%) 和良好的安全性,使其优于Zostavax.
- 疫苗接种对于50岁及以上的IBD患者和服用高风险药物如JAK抑制剂的年轻患者至关重要.
- 为加强预防,建议采用个性化疫苗接种策略,考虑疾病严重程度,药物和种族.
结论:
- 疹杆疫苗接种对于患有炎症性肠道疾病的患者至关重要,特别是那些接受免疫抑制治疗的人.
- 辛格瑞克斯是免疫功能低下的IBD患者的首选疫苗.
- 需要进一步的研究来评估Shingrix在年轻IBD患者的长期有效性,并为各种人群提供适应的疫苗接种指南.
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