出生后的动态肺气化不会阻碍早产羔羊的肺血流
Arun Sett1,2,3, Jennifer Truong4,5, Anna Crotty4,2,5
1Neonatal Research, Murdoch Children's Research Institute, Melbourne, Victoria, Australia arun.sett@mcri.edu.au.
概括
出生时的动态正极呼气压 (PEEP) 不会影响早产羔羊的肺血流 (PBF),无论使用带紧方法. 这种通风策略是安全的PBF在立即和推迟绳索紧.
科学领域:
- 新生儿生理学 新生儿生理学
- 呼吸系统医学 呼吸系统医学
- 心血管生理学心血管生理学
背景情况:
- 已知动态正极呼气压 (PEEP) 可以减少早产羔羊的肺损伤.
- 动态PEEP对肺血流 (PBF) 在即时 (ICC) 和延迟带紧 (DCC) 期间的影响以前没有被研究过.
研究的目的:
- 评估动态PEEP对PBF在早产羔羊的DCC和ICC期间的影响.
- 评估动态PEEP在直接新生儿时期对肺循环的安全性.
主要方法:
- 过早出生的羊羔用动态PEEP (8-14cmH2O) 或静态PEEP (8cmH2O) 进行通风.
- 羊羔接受了DCC或ICC (30秒紧).
- 使用心声学测量肺血流量,随着时间的推移记录了通风和PBF参数.
主要成果:
- 在DCC或ICC期间,在动态和静态PEEP组之间没有观察到PBF的显著差异.
- 在所有组中,随着时间的推移,PBF显著增加,独立于绳索管理策略.
- 在DCC期间,脑血流随着时间的推移而减少,但在ICC期间保持稳定.
结论:
- 在出生后使用动态PEEP的选择性肺部招募不会对早产羔羊的PBF产生负面影响.
- 动态PEEP是一种潜在的安全通风策略,用于早产新生儿,不论带紧的持续时间.
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