[一次性腹腔癌重复复发的病例完全通过多学科治疗治愈]
Yoshimi Hirohashi1, Kazuya Uchikawa, Chieko Hotta
1Dept. of Surgery, Takagi Hospital.
Gan to kagaku ryoho. Cancer & chemotherapy
|May 13, 2025
概括
本案例研究突出了一个罕见的初级腹膜癌的例子,最初被误诊为直肠癌复发. 卡博普拉丁和多塞塔克塞尔化学疗法的有效治疗导致了长期缓解.
科学领域:
- 在瘤学瘤学.
- 妇科瘤学 妇科瘤学
- 胃肠道瘤学 胃肠道瘤学
背景情况:
- 一名56岁的女性患有晚期直肠癌 (T4aN1M0) 接受了手术和随后的治疗.
- 最初对直肠癌淋巴转移的怀疑因组织学发现表明卵巢癌而复杂化.
- 患者经历了局部复发和进展,尽管各种化疗方案.
研究的目的:
- 报告一个具有挑战性的初级腹癌病例,最初被误诊为直肠癌.
- 描述这种罕见恶性瘤的诊断和治疗过程.
- 评估特定化疗方案在治疗复发性疾病中的有效性.
主要方法:
- 对直肠癌的低前切除和随后的疑似转移性淋巴结的切除.
- 化疗方案包括FOLFOX,化疗放射治疗 (S-1+39 Gy),FOLFIRI+cetuximab,以及碳白金/多克塞尔 (DC疗法).
- 诊断成像 (CT,PET-CT) 和组织病理学/免疫组织化学检查用于诊断和监测.
主要成果:
- 组织病理学和免疫组织化学强烈建议初级腹膜癌,而不是直肠癌转移.
- 患者在使用FOLFIRI+cetuximab时呈现瘤进展,但对DC治疗有显著的反应.
- 复发性病变在9次DC疗程后完全消失,患者在7年内没有复发.
结论:
- 准确的诊断至关重要,因为最初的表现可能会误导,模仿其他恶性瘤.
- 在这种情况下,卡博普拉丁和多塞塔克塞尔 (DC) 治疗在治疗复发性初级腹癌方面表现出显著的疗效.
- 这一案例凸显了考虑替代诊断和根据确定的病理学发现量身定制治疗的重要性.
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