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在卵巢瘤患者的肠道微生物群的特征和潜在诊断价值
Wangang Gong1,2, Gulei Jin3, Yejiang Bao1,2
1Zhejiang Cancer Hospital, Banshan Road, Hangzhou, 310022, Zhejiang, China.
Scientific reports
|May 13, 2025
概括
在卵巢瘤中,肠道微生物群的组成不同. 像Escherichia_Shigella这样的特定细菌的增加,而其他细菌的减少,有助于区分健康个体和卵巢瘤患者.
科学领域:
- 微生物组研究的研究.
- 胃肠病学 胃肠病学
- 在瘤学瘤学.
背景情况:
- 肠道微生物群在癌症的发展中起着重要作用.
- 与卵巢瘤相关的特定肠道微生物特征尚不清楚.
研究的目的:
- 为了研究健康对照组,卵巢瘤患者和良性卵巢瘤患者之间的肠道微生物组成的差异.
- 为了识别特定的肠道细菌,可以区分这些群体.
主要方法:
- 从健康对照组 (HC),卵巢瘤 (OT) 患者和良性卵巢瘤 (OBT) 患者收集了便样本.
- 使用16S rRNA测序来分析肠道微生物群的组成.
- 采用随机森林模型来评估已识别的细菌的诊断潜力.
主要成果:
- 肠道微生物群的组成,丰富性和多样性在OT患者和HC/OBT组之间有显著差异.
- 与HC相比,OT组的Escherichia_Shigella的发生率较高,而Coprococcus,Fusicatenibacter,Butyricicoccus和Oscillibacter的发生率较低.
- 随机森林模型显示,良性卵巢瘤的曲线下的面积 (AUC) 为0.77,卵巢癌的面积为0.86,表明具有良好的区分能力.
结论:
- 在患有卵巢瘤的患者中,肠道微生物群的概况与健康人群和患有良性瘤的人群相比是不同的.
- 增加的Escherichia_Shigella和某些其他细菌的水平降低与卵巢瘤有关.
- 肠道微生物群的分析,特别是埃舍里希亚_希格拉菌的丰富性,显示出区分卵巢瘤患者和健康个体的潜力.
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