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在非神经内分泌的垂体瘤下垂体缺陷症:一个系统的审查

Fernando Guerrero-Pérez^1,2, Natalia Vega Rojas³, Pedro Iglesias^4,5

¹Department of Endocrinology and Nutrition, Hospital Universitari de Bellvitge, Barcelona, Spain. fguerrerop@bellvitgehospital.cat.

Reviews in endocrine & metabolic disorders

|May 13, 2025

概括

非神经内分泌性垂体瘤 (非PitNETs) 在大约一半的患者中会导致垂体下垂体,而近20%的患者则会出现氨酸血管压素缺乏症 (AVD). 垂体转移和膜瘤更具攻击性,影响垂体功能比脑膜瘤更大.

科学领域:

内分泌学在内分泌学.
神经外科神经外科
在瘤学瘤学.

背景情况:

在非神经内分泌性垂体瘤 (非PitNETs) 中缺陷垂体功能并未得到充分证实.
现有的证据有限,分布在各种瘤类型中.

研究的目的:

在一系列非PitNET中系统地审查和分析垂体功能障碍.
为了确定不同非PitNET类型的hypopituitarism和 arginine vasopressin缺乏症 (AVD) 的患病率.

主要方法:

对PubMed,Embase,Scopus和Cochrane数据库进行系统审查.
包括在35年内评估阴道瘤,脑膜瘤,胚芽瘤,淋巴瘤,阴道细胞瘤,颗粒细胞瘤,细胞瘤和转移中的垂体功能的研究.
分析了114项研究中的5614名患者的数据.

主要成果:

整体下垂体病的患病率为49.1%,AVD的患病率为18.4%.
患病率因瘤类型而异:生殖细胞瘤 (67.3%),转移 (61.4%),淋巴瘤 (58.7%),垂体细胞瘤 (54.4%),细胞瘤 (53.8%),状瘤 (49.1%),颗粒细胞瘤 (29.7%) 和脑膜瘤 (11.5%).
与脑膜瘤相比,垂体转移和喉瘤显示出明显更高的hypopituitarism率.

结论:

非PitNETs经常导致阴下垂体和AVD.
下垂体转移和膜瘤表现出更大的局部侵略性,导致比脑膜瘤更显著的下垂体-下垂体功能障碍.

关键词:

喉瘤是一种瘤.细菌和胚胎的生长方式这种情况叫做hypopituitarism.阴道瘤是发生在阴道上的人.皮图基细胞瘤是什么?下垂体转移的发生.

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