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Updated: May 5, 2026

Determining the Likelihood of Variant Pathogenicity Using Amino Acid-level Signal-to-Noise Analysis of Genetic Variation
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Determining the Likelihood of Variant Pathogenicity Using Amino Acid-level Signal-to-Noise Analysis of Genetic Variation

Published on: January 16, 2019

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使用大型语言模型在临床开发中对协议偏差进行先进和灵活的标记.

Min Zou1, Leszek Popko2, Michelle Gaudio3

  • 1F.Hoffmann-La Roche AG, 4070, Basel, Switzerland. elaine.zou@roche.com.

Therapeutic innovation & regulatory science
|May 13, 2025
PubMed
概括

一种新的大型语言模型 (LLM) 方法自动化了协议偏差 (PD) 分类,提高了临床试验的效率. 这种方法快速识别有影响力的PDs,增强人类受试者保护和临床开发中的疾病进展评估.

关键词:
良好的临床实践 良好的临床实践大型语言模型.协议的偏差 协议的偏差质量保证 质量保证 质量保证研究管理研究管理

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