探索卢旺达5岁以下儿童中营养状况和无症状疟疾之间的流行率和关联:横截面分析
Aline Uwimana1,2,3, Annie Robert4, Ayman Ahmed2
1Metabolism and Nutrition Research Group, Louvain Drug Research Institute (LDRI), UCLouvain, Université Catholique de Louvain, Brussels, Belgium.
Malaria journal
|May 13, 2025
概括
营养不良,包括发育迟缓和体重不足,显著增加了卢旺达五岁以下儿童无症状疟疾的风险. 这突出了关键的双重负担,需要针对弱势群体进行综合健康干预.
科学领域:
- 公共卫生 公共卫生
- 传染性疾病 传染性疾病
- 儿科 儿科 儿科
- 营养流行病学 营养流行病学
背景情况:
- 营养不良和疟疾是全球重大卫生挑战,特别是在非洲.
- 卢旺达对无症状疟疾及其与营养状况相关的研究是有限的.
- 这项研究通过调查卢旺达儿童营养健康和无症状疟疾之间的关系来弥补这一差距.
研究的目的:
- 调查卢旺达儿童的营养状况和无症状疟疾感染之间的关系.
- 评估营养不良和无症状疟疾的流行情况.
- 为了检查衰退,衰减,体重不足和无症状疟疾之间的联系.
主要方法:
- 利用了来自卢旺达三个人口和健康调查 (2010,2014-15,2019-20年) 的数据.
- 包括10,411名年龄在6-59个月的儿童,确诊疟疾 (血).
- 运用后勤回归计算几率比率 (OR) 和调整的几率比率 (AOR) 来计算营养状况和疟疾结果,控制共变量.
主要成果:
- 无症状疟疾的患病率为1.3% (140/10,411);38.3%的儿童发育不良.
- 发育迟缓 (OR=1.85,p<0.001) 和体重不足 (AOR=1.59,p=0.01) 与疟疾风险增加有显著联系.
- 在24个月以上的儿童中,疟疾风险更高 (AOR=2.72,p<0.001),而来自最富裕家庭的儿童显示出保护 (AOR=0.38,p<0.001).
结论:
- 发育迟缓,体重不足和较低的社会经济地位是卢旺达幼儿无症状疟疾的重要危险因素.
- 一个有害的循环存在,疟疾可以加剧营养不良,反之亦然.
- 针对营养状况和疟疾的综合监测和干预措施对于流行地区的儿童至关重要.
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