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炎症性肠道疾病中肠道和肠外癌症的危险因素:一个回顾性单中心队列研究
Rosa Rosania1, Maximilian Nord1, Florian G Scurt2
1Department of Gastroenterology, Hepatology and Infectious Diseases, Otto-von-Guericke University Hospital, 39120 Magdeburg, Germany.
炎症性肠病 (IBD) 患者患癌症的风险增加了两倍. 结肠直肠和淋巴瘤的风险可能会增加,特别是在组合疗法,需要个性化癌症监测.
科学领域:
- 胃肠病学 胃肠病学
- 在瘤学瘤学.
- 流行病学 流行病学
背景情况:
- 患有炎症性肠病 (IBD) 的患者患肠道和肠外癌症的风险较高.
- 量化癌症风险和确定IBD患者的相关风险因素对于主动管理至关重要.
研究的目的:
- 以追溯评估癌症发病率,并确定IBD患者队列中的风险因素.
- 使用标准化发病率 (SIR) 将IBD患者的癌症风险与普通人群进行比较.
主要方法:
- 对560名IBD患者的流行病学数据,疾病特征和癌症发生率的回顾性分析.
- 计算危险比率 (HRs) 和标准化发病率比率 (SIRs) 以估计癌症风险.
- 数据收集时间从2021年1月到2022年2月.
主要成果:
- 患有IBD的患者患任何癌症的风险增加了两倍 (SIR 1.94).
- 大肠直肠癌 (29%),皮肤癌 (19%) 和乳腺癌 (17%) 是最常见的. 女性患整体癌症,黑色素瘤和CRC的风险更高;男性患淋巴瘤的风险更高.
- 在IBD诊断时的年龄较小和免疫调节剂的使用 (单独或与生物药物一起) 与癌症风险增加有关.
结论:
- 在IBD患者中,结直肠癌和淋巴瘤的风险可能超过以前的估计,可能是由于组合治疗的使用.
- 在IBD疾病的整个过程中,定期进行个性化癌症风险评估至关重要.
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