甲状腺功能障碍与妊娠期多质瘤相关:系统性文献综述和途径分析
Alina Badlaeva1, Anna Tregubova1, Aleksandra Asaturova1
11st Pathology Department, National Medical Research Center for Obstetrics, Gynecology and Perinatology Named After Academician V.I. Kulakov of the Ministry of Health of Russia, Bldg. 4, Oparina Street, Moscow 117513, Russia.
妊娠期形瘤 (GTN) 可以通过增加形细胞的增殖和人类胆固醇激素 (hCG) 与甲状腺激素的交叉反应引起甲状腺功能障碍. 甲状腺功能过高的症状通常在GTN治疗后消失.
科学领域:
- 妇科 妇科医生 妇科
- 内分泌学 在内分泌学.
- 在瘤学瘤学.
背景情况:
- 孕期 trofhoblastic 疾病 (GTD) 涵盖了各种繁殖性疾病.
- 甲状腺功能障碍症是一种罕见的GTD并发症,包括孕期热囊细胞瘤 (GTN).
研究的目的:
- 系统地审查与甲状腺功能障碍相关的组织学证实GTN病例.
- 描述临床病理特征,阐明GTD中甲状腺功能过高的途径.
主要方法:
- 按照PRISMA指南进行系统的文献审查.
- 搜索了PubMed,科学网和Scopus的GTN和甲状腺功能障碍病例.
- 描述了临床病理学特征和甲状腺功能过高的机制.
主要成果:
- 确定了32种胆 ?? 瘤和1种与甲状腺功能障碍相关的PSTT.
- 转移通常影响肺部 (53%),大脑 (25%) 和肝脏 (19%).
- 甲状腺功能过高的症状在治疗后2-3周内显著改善.
结论:
- 增加的 trofhoblast 增殖和人类胆管性腺激素 (hCG) 与甲状腺刺激激素的交叉反应有助于GTN中的甲状腺功能过高.
- 升高的hCG水平及其异型可能会刺激甲状腺功能.
- 在GTN中甲状腺功能过高是可以治疗的,并通过GTN管理来解决.
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