转移性HR+/HER2-乳腺癌的治疗顺序:一个德尔菲共识
Lazar Popović1, Simona Borštnar2, Ivana Božović-Spasojević3
1Oncology Institute of Vojvodina, Faculty of Medicine, University of Novi Sad, 21000 Novi Sad, Serbia.
Cancers
|May 14, 2025
概括
专家建议下一代测序用于HR+/HER2-转移性乳腺癌 (mBC) 进展的基因组表征. 治疗选择取决于特定的突变,尽管临床实践因治疗可用性而有所不同.
科学领域:
- 在瘤学瘤学.
- 基因组学就是基因组学.
- 临床试验 临床试验
背景情况:
- HR+/HER2-转移性乳腺癌 (mBC) 的治疗环境正在迅速发展.
- 由于临床因素和生物标志物状态,选择二线 (2L) 疗法可能是复杂的.
研究的目的:
- 为HR+/HER2-mBC建立专家共识,以确定HR+/HER2-mBC的最佳二线和超越治疗策略.
- 根据生物标志物状态和临床试验数据指导治疗决策.
主要方法:
- 一个两轮的德尔菲共识,涉及10名HR+/HER2-mBC专家.
- 专家评估了38个关于生物标志物测试和2L和随后的治疗线的治疗选择的陈述.
主要成果:
- 在38个陈述中,就37个陈述达成共识.
- 建议在一线治疗进展后进行下一代测序以进行基因组表征.
- 治疗选择以特定突变为指导,承认可用性和报销的实际限制.
结论:
- 通过下一代测序进行基因组表征对于疾病进展至关重要.
- 应根据已识别的突变量身定制治疗策略.
- 由于现实世界的约束,临床实践可能与共识建议有所不同.
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