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Updated: May 15, 2025

Development of a Backbone Cyclic Peptide Library as Potential Antiparasitic Therapeutics Using Microwave Irradiation
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制备和封装DPP-IV抑制:功能性食品开发的挑战和策略

Rui Zhao1,2,3, Ye Zhou1,2,3, Huifang Shen1,2,3

  • 1Food Processing Research Institute, Heilongjiang Academy of Agricultural Sciences, Harbin 150086, China.

Foods (Basel, Switzerland)
|May 14, 2025
PubMed
概括

双基酸酶IV (DPP-IV) 抑制对改善血糖控制的2型糖尿病管理有希望. 本综述涵盖了它们的生产,封装以及作为功能性食品成分使用的挑战.

关键词:
这是一种DPP-IV抑制.生物信息学是一种生物信息学.封装的封装方式酶性水解是一种酶性水解.发酵 发酵 发酵 发酵

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Dipeptidyl Peptidase 4 Inhibitors

Dipeptidyl peptidase 4 (DPP-4) is a serine protease widely distributed in the body. It's involved in the inactivation of GLP-1 and GIP hormones, which are crucial for insulin regulation. DPP-4 inhibitors, such as sitagliptin (Januvia), saxagliptin (Onglyza), linagliptin (Tradjenta), alogliptin (Nesina), and vildagliptin (Galvus), help increase the proportion of active GLP-1, enhancing insulin secretion. These inhibitors work by competitively binding to DPP-4. This binding causes a...
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Glucagon-like Receptor Agonists

Incretins include glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP), which stimulate insulin secretion post-meals. In type 2 diabetes, GIP's efficacy is reduced, making GLP-1 a viable drug target. GIP originates from preproGIP.
GLP-1, when administered in high doses intravenously, triggers insulin secretion, inhibits glucagon release, slows gastric emptying, reduces food intake, and restores normal insulin secretion. However, its rapid inactivation by...
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The endoplasmic reticulum (ER) of pancreatic β-cells synthesizes preproinsulin, which consists of a signal peptide, A and B chains, and a C-peptide. Preproinsulin is then cleaved and folded into proinsulin, which translocates to the Golgi apparatus for sorting and packaging into secretory granules. In these granules, enzymatic clipping generates insulin and C-peptide.
Damage or functional impairment of β-cells inhibits insulin production, leading to diabetes. Diabetes treatment...
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