更年期和糖尿病风险,以及β细胞功能和胰岛素敏感性轨迹:基于社区的队列研究
1College of Nursing, Gyeongsang National University, Jinju-si 52727, Republic of Korea.
Healthcare (Basel, Switzerland)
|May 14, 2025
概括
糖尿病风险在更年期前增加,而在更年期后降低,独立于年龄和肥胖. 胰岛素敏感性和β细胞功能的下降在女性糖尿病发病之前.
科学领域:
- 内分泌学 在内分泌学.
- 生殖健康 生殖健康
- 代谢综合征是代谢综合征的一种.
背景情况:
- 更年期和糖尿病风险之间的联系仍然不完全理解,先前的研究表明只有一个微弱的关联.
- 这项研究调查了糖尿病风险,胰腺β细胞功能和更年期过渡期间胰岛素敏感性的动态变化.
研究的目的:
- 分析糖尿病风险,β细胞功能和胰岛素敏感性在不同更年期阶段的变化.
- 确定这些生理变化与患糖尿病的风险之间的关系.
主要方法:
- 一项为期16年的基于社区的队列研究,涉及1224名女性和6684次访问.
- 在更年期前,更年期前和更年期后阶段对糖尿病风险的分析.
- 评估β细胞功能和胰岛素敏感性指数,根据更年期和肥胖的年龄进行调整,使用通用估计方程和线性混合模型.
主要成果:
- 糖尿病发病率为18.6%;每年糖尿病风险在绝经前增加 (OR 1.03) 并在绝经后减少 (OR 0.96).
- 患有发病糖尿病的女性表现出胰岛素敏感性和β细胞功能下降,导致偏向指数降低.
- 胰岛素敏感度的显著变化,特别是在糖尿病发病之前,显着增加了糖尿病风险 (OR 1.88).
结论:
- 绝经前期间与糖尿病风险增加有关,不论绝经年龄或肥胖.
- 胰岛素敏感度的连续下降,其次是β细胞功能,与糖尿病风险有关.
- 这些发现澄清了与更年期相关的糖尿病风险和胰岛素动态,强调了在更年期过渡期间需要主动健康管理的需要.
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