肥胖和高脂肪饮食诱导的神经炎症:对自主神经系统功能障碍和内皮疾病的影响
Galateia Stathori1, Nikolaos F Vlahos2, Evangelia Charmandari1,3
1Center for the Prevention and Management of Overweight and Obesity, Division of Endocrinology, Metabolism and Diabetes, First Department of Pediatrics, Medical School, National and Kapodistrian University of Athens, 'Aghia Sophia' Children's Hospital, 11527 Athens, Greece.
肥胖和高脂肪饮食导致大脑炎症,导致自主神经系统 (ANS) 功能障碍和内皮疾病. 脑下垂体炎症是将这些疾病联系在一起的关键因素.
科学领域:
- 神经科学是一个神经科学.
- 心血管科学 心血管科学
- 代谢障碍 代谢障碍 代谢障碍
背景情况:
- 肥胖和高脂肪饮食 (HFD) 与心血管疾病和内皮功能障碍等严重健康问题有关.
- 神经炎症,特别是在下丘脑,与肥胖和HFD相关.
- 自主神经系统 (ANS) 功能障碍有助于内皮疾病,其中心控制在下丘脑和脑干中.
研究的目的:
- 调查肥胖和HFD诱导的神经炎症是否会破坏 ANS 中央结构,导致 ANS 功能障碍和内皮疾病.
- 确定神经炎症在肥胖,ANS功能障碍和内皮问题之间的联系中的作用.
主要方法:
- 审查科学文献检查肥胖,HFDs,神经炎症,ANS功能和内皮健康之间的联系.
- 对参与肥胖引起的下丘脑炎症的分子机制的分析.
主要成果:
- 肥胖和HFD的下丘脑炎症与交感性过活和内皮疾病相关.
- 确定的关键分子通路包括炎症性细胞因子,NF-κB/IKK-β激活,血管酶二介导的微质激活,循环线粒体诱导的cGAS激活和TLR4通路刺激.
结论:
- 脑下垂体炎症似乎是肥胖/HFD,ANS功能障碍和内皮疾病之间的关系的核心.
- 针对下丘脑炎症可能为与肥胖有关的心血管并发症提供治疗策略.
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